CSF1R Monoclonal Antibody (604B5 2E11) | Invitrogen MA5-16532 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CSF1R Monoclonal Antibody (604B5 2E11)

catalog :

MA5-16532

quantity :

1 mg

price :

US 1096.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

604B5 2E11

reactivity :

mouse, rat

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

CSF1R Monoclonal Antibody (604B5 2E11)

Catalog # :

MA5-16532

Quantity :

1 mg

Price :

US 1096.00

Clonality :

Monoclonal

Purity :

Ion-exchange chromatography

Host :

Rat

Reactivity :

Mouse, Rat

Applications :

Flow Cytometry: 1:25-1:50, Functional assay: Assay-dependent

Species :

Mouse, Rat

Clone :

604B5 2E11

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

CSF1R (colony stimulating factor 1 receptor) is a cytokine that controls the production, differentiation, and function of macrophages. CSF1R mediates most if not all of the biological effects of CSF1. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

Immunogen :

RAW 264 cells

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:25-1:50, Functional assay: Assay-dependent

Aliases :

AI323359; CD115; CD115 antigen; C-FMS; colony stimulating factor 1 receptor; colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1 receptor; CSF1R; CSF-1R; CSF-1-R; CSFIR; Csfmr; CSFR; EC 2.7.10.1; FIM2; Fim-2; FMS; fms proto-oncogene; HDLS; kinase CSFR; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; M-CSFR; M-CSF-R; mrfms; OTTHUMP00000224093; protein-tyrosine kinase; proto-oncogene c-Fms; proto-oncogene fms