This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD11b Monoclonal Antibody (5C6)
catalog :
MA5-16528
quantity :
500 ug
price :
US 582.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
5C6

The same clone is also sold as:
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
citations: 9
Reference
Galv xe1 n Hern xe1 ndez A, G xf3 mez Gaviria M, Mart xed nez Duncker I, Mart xed nez xc1 lvarez J, Mora Montes H. Differential Recognition of Clinically Relevant Sporothrix Species by Human Granulocytes. J Fungi (Basel). 2023;9: pubmed publisher
Petrie Hanson L, Peterman A. Trained Immunity Provides Long-Term Protection against Bacterial Infections in Channel Catfish. Pathogens. 2022;11: pubmed publisher
Liu Y, Zhang X, Hu Y, Kang M, Wu Y, Wang Y, et al. Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway. Exp Ther Med. 2022;24:654 pubmed publisher
Neves G, Wong S, Aimanianda V, Simenel C, Guijarro J, Walls C, et al. Complement-Mediated Differential Immune Response of Human Macrophages to Sporothrix Species Through Interaction With Their Cell Wall Peptidorhamnomannans. Front Immunol. 2021;12:749074 pubmed publisher
Peng Z, Zhao C, Du X, Yang Y, Li Y, Song Y, et al. Autophagy Induced by Palmitic Acid Regulates Neutrophil Adhesion Through the Granule-Dependent Degradation of αMβ2 Integrin in Dairy Cows With Fatty Liver. Front Immunol. 2021;12:726829 pubmed publisher
Ito T, Shintani Y, Fields L, Shiraishi M, Podaru M, Kainuma S, et al. Cell barrier function of resident peritoneal macrophages in post-operative adhesions. Nat Commun. 2021;12:2232 pubmed publisher
Zhou Y, Miles J, Tavori H, Lin M, Khoshbouei H, Borchelt D, et al. PMP22 regulates cholesterol trafficking and ABCA1-mediated cholesterol efflux. J Neurosci. 2019;: pubmed publisher
Murinello S, Usui Y, Sakimoto S, Kitano M, Aguilar E, Friedlander H, et al. miR-30a-5p inhibition promotes interaction of Fas+ endothelial cells and FasL+ microglia to decrease pathological neovascularization and promote physiological angiogenesis. Glia. 2019;67:332-344 pubmed publisher
Lin H, Faunce D, Stacey M, Terajewicz A, Nakamura T, Zhang Hoover J, et al. The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med. 2005;201:1615-25 pubmed
product information
Product Type :
Antibody
Product Name :
CD11b Monoclonal Antibody (5C6)
Catalog # :
MA5-16528
Quantity :
500 ug
Price :
US 582.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Rat
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 1:50-1:100, Functional Assay: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent
Species :
Human, Mouse
Clone :
5C6
Isotype :
IgG2b
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Immunogen :
Thioglycollate-elicted Peritoneal Macrophages (TPM)
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:50-1:100, Functional Assay: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent
Aliases :
antigen CD11b (p170); antigen CD11b (p170); macrophage antigen alpha polypeptide; CD11 antigen-like family member B; CD11b; CD11B (p170); CD11b/CD18; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component receptor 3 alpha-a; complement receptor type 3; CR3; CR-3 alpha chain; CR3A; F730045J24Rik; integrin alpha M; integrin alpha-M; integrin subunit alpha M; integrin, alpha M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; leukocyte integrin alpha-M chain; LOC100351865; Ly-40; MAC1; Mac-1; Mac-1 alpha; Mac-1 alpha (Mac1A); MAC-1 alpha subunit; MAC1A; Mac-1a; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6; unnamed protein product
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA