CD19 Monoclonal Antibody (SP110) | Invitrogen MA5-16414 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD19 Monoclonal Antibody (SP110)

catalog :

MA5-16414

quantity :

500 uL

price :

US 612.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SP110

reactivity :

human, mouse

application :

immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:50; loading ...; fig 1c	Khosravi Maharlooei M, Li H, Hoelzl M, Zhao G, Ruiz A, Misra A, et al. Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice. J Autoimmun. 2021;119:102612 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD19 Monoclonal Antibody (SP110)

Catalog # :

MA5-16414

Quantity :

500 uL

Price :

US 612.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:40-1:100, Immunohistochemistry (Paraffin): 1:200

Species :

Human

Clone :

SP110

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.

Immunogen :

Synthetic peptide corresponding to C-terminus of human CD19.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:40-1:100, Immunohistochemistry (Paraffin): 1:200

Aliases :

AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Cd19; CD19 antigen; CD19 molecule; CVID3; differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12

more info or order :

Invitrogen product webpage