Carbonic Anhydrase IX Monoclonal Antibody (SP106) | Invitrogen MA5-16413 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Carbonic Anhydrase IX Monoclonal Antibody (SP106)

catalog :

MA5-16413

quantity :

500 uL

price :

US 592.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SP106

The same clone is also sold as:

Abcam: ab105226

reactivity :

human

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 2

Reference
Ravid Lustig L, Sampath Kumar A, Schw xe4 mmle T, Dunkel I, Noviello G, Limberg E, et al. GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. Nat Cell Biol. 2023;25:1704-1715 pubmed publisher
Genolet O, Monaco A, Dunkel I, Boettcher M, Schulz E. Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach. Genome Biol. 2021;22:110 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Carbonic Anhydrase IX Monoclonal Antibody (SP106)

Catalog # :

MA5-16413

Quantity :

500 uL

Price :

US 592.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:100, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:500

Species :

Human

Clone :

SP106

Isotype :

IgG

Storage :

4 C, do not freeze

Description :

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Immunogen :

Synthetic peptide derived from human CA-9.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:100, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:500

Aliases :

Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250