Thymidylate Synthase Monoclonal Antibody (SP112) | Invitrogen MA5-16405 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Thymidylate Synthase Monoclonal Antibody (SP112)

catalog :

MA5-16405

quantity :

500 uL

price :

US 622.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SP112

The same clone is also sold as:

Abcam: ab111153

reactivity :

human

application :

immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Thymidylate Synthase Monoclonal Antibody (SP112)

Catalog # :

MA5-16405

Quantity :

500 uL

Price :

US 622.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:200, Immunohistochemistry (Paraffin): 1:100

Species :

Human

Clone :

SP112

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Immunogen :

Synthetic peptide near C-terminus of human TS.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:200, Immunohistochemistry (Paraffin): 1:100

Aliases :

HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy