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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Synaptophysin Monoclonal Antibody (SP11)
catalog :
MA5-16402
quantity :
500 uL
price :
US 474.00
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
SP11
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 46
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 2a
Mu P, Zhang Z, Benelli M, Karthaus W, Hoover E, Chen C, et al. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science. 2017;355:84-88 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 4d
De Luca Johnson J, Zenali M. A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma. Case Rep Pathol. 2016;2016:9063634 pubmed
  • immunohistochemistry - paraffin section; human; 1:50; loading ...
George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel A, et al. Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer. Clin Cancer Res. 2017;23:1220-1226 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:50; tbl 3
  • immunohistochemistry - frozen section; mouse; 1:50; tbl 3
Bahia El Idrissi N, Bosch S, Ramaglia V, Aronica E, Baas F, Troost D. Complement activation at the motor end-plates in amyotrophic lateral sclerosis. J Neuroinflammation. 2016;13:72 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 3
Choi S, Chen Z, Tang L, Fang Y, Shin S, Panarelli N, et al. Bcl-xL promotes metastasis independent of its anti-apoptotic activity. Nat Commun. 2016;7:10384 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
Böger C, Haag J, Egberts J, Röcken C. Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder. Pathol Res Pract. 2016;212:54-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Projetti F, Serrano E, Vergez S, Bissainthe A, Delisle M, Uro Coste E. Is neuroendocrine differentiation useful to discriminate primary sinonasal intestinal-type adenocarcinomas from metastatic colorectal adenocarcinomas?. J Clin Pathol. 2015;68:79-82 pubmed publisher
  • immunohistochemistry; human; 1:100; fig s1
Hijioka S, Hosoda W, Mizuno N, Hara K, Imaoka H, Bhatia V, et al. Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?. J Gastroenterol. 2015;50:564-72 pubmed publisher
  • immunohistochemistry; human; 1:200
Milione M, Gasparini P, Sozzi G, Mazzaferro V, Ferrari A, Casali P, et al. Ewing sarcoma of the small bowel: a study of seven cases, including one with the uncommonly reported EWSR1-FEV translocation. Histopathology. 2014;64:1014-26 pubmed publisher
  • immunohistochemistry; human; 1:100
Altinay S, Kusaslan R. Gastrointestinal autonomic nerve tumour of jejunum presenting as a perforated mass. J Pak Med Assoc. 2014;64:461-4 pubmed
  • immunohistochemistry; human; 1:100
Lee J, Yu C, Kim M, Hong S, Lim S, Kim J. Prognostic impact of diagnosing colorectal neuroendocrine carcinoma using the World Health Organization 2010 classification. Surgery. 2014;155:650-8 pubmed publisher
  • immunohistochemistry; human; 1:100
Chang T, Lin H, Rogers K, Brame L, Yeh M, Yang Q, et al. Expression of aldo-keto reductase family 1 member C3 (AKR1C3) in neuroendocrine tumors & adenocarcinomas of pancreas, gastrointestinal tract, and lung. Int J Clin Exp Pathol. 2013;6:2419-29 pubmed
  • immunohistochemistry; human; 1:100
Hasegawa T, Yamao K, Hijioka S, Bhatia V, Mizuno N, Hara K, et al. Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors. Endoscopy. 2014;46:32-8 pubmed publisher
  • immunohistochemistry; human; 1:200
Lopez F, Costales M, Vivanco B, Fresno M, Suarez C, Llorente J. Sinonasal desmoplastic small round cell tumor. Auris Nasus Larynx. 2013;40:573-6 pubmed publisher
  • immunohistochemistry; human
Thiery Lavenant G, Zavalin A, Caprioli R. Targeted multiplex imaging mass spectrometry in transmission geometry for subcellular spatial resolution. J Am Soc Mass Spectrom. 2013;24:609-14 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • immunohistochemistry; human
Mosquera J, Beltran H, Park K, MacDonald T, Robinson B, Tagawa S, et al. Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia. 2013;15:1-10 pubmed
  • immunohistochemistry; human; 1:100
Masago K, Hosada W, Sasaki E, Murakami Y, Sugano M, Nagasaka T, et al. Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature. Case Rep Oncol. 2012;5:471-8 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Pan J, Yeger H, Ratcliffe P, Bishop T, Cutz E. Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice. Adv Exp Med Biol. 2012;758:149-55 pubmed publisher
  • immunohistochemistry; human; 1:100
Zhao L, Luo J, Zhang H, Da J. Pigmented paraganglioma of the kidney: a case report. Diagn Pathol. 2012;7:77 pubmed publisher
  • immunohistochemistry; human; 1:100
Righi L, Rapa I, Votta A, Papotti M, Sapino A. Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma. Virchows Arch. 2012;460:415-21 pubmed publisher
  • immunohistochemistry; human
Asioli S, Righi A, de Biase D, Morandi L, Caliendo V, Picciotto F, et al. Expression of p63 is the sole independent marker of aggressiveness in localised (stage I-II) Merkel cell carcinomas. Mod Pathol. 2011;24:1451-61 pubmed publisher
  • immunohistochemistry; human; 1:100
Lee M, Cho K, Yu C, Park Y, Kim J, Kim J, et al. Perivascular epithelioid cell tumor of the sigmoid colon with transcription factor E3 expression. Ann Diagn Pathol. 2012;16:306-11 pubmed publisher
  • immunohistochemistry; mouse; 1:100
McCartney S, Vermi W, Lonardi S, Rossini C, Otero K, Calderon B, et al. RNA sensor-induced type I IFN prevents diabetes caused by a ? cell-tropic virus in mice. J Clin Invest. 2011;121:1497-507 pubmed publisher
  • immunohistochemistry; human
Eloy C, Vinagre J, Cameselle Teijeiro J, Paiva M, Soares P, Sobrinho Simoes M. Tumor-in-tumor of the thyroid with basaloid differentiation: a lesion with a solid cell nest neoplastic component?. Int J Surg Pathol. 2011;19:276-80 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 2, 3, 4
Baydar D, Kulac I, Gurel B, De Marzo A. A case of prostatic adenocarcinoma with aberrant p63 expression: presentation with detailed immunohistochemical study and FISH analysis. Int J Surg Pathol. 2011;19:131-6 pubmed publisher
  • immunohistochemistry; human; 1:125
Buresh C, Oliai B, Miller R. Reactivity with TdT in Merkel cell carcinoma: a potential diagnostic pitfall. Am J Clin Pathol. 2008;129:894-8 pubmed publisher
  • immunohistochemistry; human; 1:400
Skalova A, Sima R, Bohus P, Curik R, Lukas J, Michal M. Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene. Pathol Res Pract. 2008;204:599-606 pubmed publisher
  • immunohistochemistry; human
Strojan Flezar M, Srebotnik Kirbis I. Identification of carcinoma origin by thyroid transcription factor-1 immunostaining of fine needle aspirates of metastases. Cytopathology. 2009;20:176-82 pubmed publisher
  • immunohistochemistry; human; 1:100
Eisenthal A, Trejo L, Shtabsky A, Bedny F, Brazowski E. A novel assessment of the quality of immunohistostaining overcomes the limitations of current methods. Pathol Res Pract. 2008;204:323-8 pubmed publisher
  • immunohistochemistry; human
Asioli S, Accinelli G, Pacchioni D, Bussolati G. Diagnosis of biliary tract lesions by histological sectioning of brush bristles as alternative to cytological smearing. Am J Gastroenterol. 2008;103:1274-81 pubmed publisher
  • immunohistochemistry; human; 1:100
Asioli S, Righi A, Volante M, Eusebi V, Bussolati G. p63 expression as a new prognostic marker in Merkel cell carcinoma. Cancer. 2007;110:640-7 pubmed
  • immunocytochemistry; mouse
Pan J, Luk C, Kent G, Cutz E, Yeger H. Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice. Am J Respir Cell Mol Biol. 2006;35:320-6 pubmed
Luan Z, Morimoto Y, Fushimi A, Yamashita N, Suo W, Bhattacharya A, et al. MUC1-C Dictates Neuroendocrine Lineage Specification in Pancreatic Ductal Adenocarcinomas. Carcinogenesis. 2021;: pubmed publisher
Jensen B, Schuldi M, McAvoy K, Russell K, Boehringer A, Curran B, et al. Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment. EMBO Mol Med. 2020;12:e10722 pubmed publisher
Yasumizu Y, Rajabi H, Jin C, Hata T, Pitroda S, Long M, et al. MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Nat Commun. 2020;11:338 pubmed publisher
Winter J, Gildea D, Andreas J, Gatti D, Williams K, Lee M, et al. Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer. Cell Syst. 2017;4:31-45.e6 pubmed publisher
Fuente Martín E, García Cáceres C, Argente Arizón P, Diaz F, Granado M, Freire Regatillo A, et al. Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes. Sci Rep. 2016;6:23673 pubmed publisher
Bolier R, Tolenaars D, Kremer A, Saris J, Pares A, Verheij J, et al. Enteroendocrine cells are a potential source of serum autotaxin in men. Biochim Biophys Acta. 2016;1862:696-704 pubmed publisher
Terris B, Genevay M, Rouquette A, Audebourg A, Mentha G, Dousset B, et al. Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour. Dig Liver Dis. 2011;43:971-4 pubmed publisher
Park S, Park C, Kim S, Jang S, Chi H, Kim M, et al. Detection of bone marrow metastases of neuroblastoma with immunohistochemical staining of CD56, chromogranin A, and synaptophysin. Appl Immunohistochem Mol Morphol. 2010;18:348-52 pubmed publisher
Yajima N, Mizukami H, Wada R, Saito F, Yagihashi S. Small cell carcinoma with skeletal muscle differentiation of urinary bladder. Pathol Int. 2009;59:748-51 pubmed publisher
Mouser P, Levy M, Sojka J, Ramos Vara J. Cerebellar abiotrophy in an alpaca (Lama pacos). Vet Pathol. 2009;46:1133-7 pubmed publisher
Baydar D, Aydin O. Confusing cases: clear cell but not renal cell lesions in kidney. Pathol Int. 2008;58:713-7 pubmed publisher
Marton E, Feletti A, Basaldella L, Dei Tos A, Bendini M, Longatti P. Atypical cystic meningioma overexpressing AQP1 in early infancy: case report with literature review. Acta Paediatr. 2008;97:1145-9 pubmed publisher
Wong S, Chan J, Lo E, Chan A, Wong M, Chan C, et al. The contribution of bifunctional SkipDewax pretreatment solution, rabbit monoclonal antibodies, and polymer detection systems in immunohistochemistry. Arch Pathol Lab Med. 2007;131:1047-55 pubmed
Volante M, La Rosa S, Castellano I, Finzi G, Capella C, Bussolati G. Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas. Virchows Arch. 2006;448:545-51 pubmed
product information
Product Type :
Antibody
Product Name :
Synaptophysin Monoclonal Antibody (SP11)
Catalog # :
MA5-16402
Quantity :
500 uL
Price :
US 474.00
Clonality :
Monoclonal
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 1:200, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:200
Species :
Human, Mouse, Rat
Clone :
SP11
Isotype :
IgG
Storage :
-20 C or -80 C if preferred
Description :
Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
Immunogen :
Synthetic peptide corresponding to C-terminus of human synaptophysin.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 1:200, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:200
Aliases :
A230093K24Rik; AI848995; BM89 antigen; I79_012252; Major synaptic vesicle protein p38; MRX96; MRXSYP; p38; Syn; Synaptophysin; Syp; Syp I; Syp1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA