Glypican 3 Monoclonal Antibody (SP86) | Invitrogen MA5-16368 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Glypican 3 Monoclonal Antibody (SP86)

catalog :

MA5-16368

quantity :

500 uL

price :

US 582.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SP86

The same clone is also sold as:

Abcam: ab95363, ab282189, ab314880, ab303587

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 2

Reference
Koksal A, Thevenot P, Aydin Y, Núñez K, Sandow T, Widmer K, et al. Impaired Autophagy Response in Hepatocellular Carcinomas Enriches Glypican-3 in Exosomes, Not in the Microvesicles. J Hepatocell Carcinoma. 2022;9:959-972 pubmed publisher
Aydin Y, Koksal A, Thevenot P, Chava S, Heidari Z, Lin D, et al. Experimental Validation of Novel Glypican 3 Exosomes for the Detection of Hepatocellular Carcinoma in Liver Cirrhosis. J Hepatocell Carcinoma. 2021;8:1579-1596 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Glypican 3 Monoclonal Antibody (SP86)

Catalog # :

MA5-16368

Quantity :

500 uL

Price :

US 582.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:80, Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:1,000

Species :

Human

Clone :

SP86

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

Immunogen :

Synthetic peptide derived from C-terminus of human glypican-3 protein.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:80, Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:1,000

Aliases :

defective in Simpson-Golabi-Behmel overgrowth syndrome; DGSX; glypican 3; glypican proteoglycan 3; glypican-3; Glypican-3 alpha subunit; Glypican-3 beta subunit; Gpc3; GTR22; GTR2-2; heparan sulphate proteoglycan; intestinal protein OCI-5; MXR7; OCI5; OCI-5; proteoglycan GPC3; SDYS; secreted glypican-3; SGB; SGBS; SGBS1