F4/80 Monoclonal Antibody (SP115) | Invitrogen MA5-16363 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

F4/80 Monoclonal Antibody (SP115)

catalog :

MA5-16363

quantity :

500 uL

price :

US 582.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SP115

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig 5e	Zhao Q, Zhou X, Kuiper R, Curbo S, Karlsson A. Mitochondrial dysfunction is associated with lipid metabolism disorder and upregulation of angiotensin-converting enzyme 2. PLoS ONE. 2022;17:e0270418 pubmed publisher
immunohistochemistry - paraffin section; rat; 1:75; fig 6	Han E, Qian H, Jiang B, Figetakis M, Kosyakova N, Tellides G, et al. A therapeutic vascular conduit to support in vivo cell-secreted therapy. NPJ Regen Med. 2021;6:40 pubmed publisher
immunohistochemistry; rat; loading ...; fig 6d	Alomar F, Singh J, Jang H, Rozanzki G, Shao C, Padanilam B, et al. Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats. Br J Pharmacol. 2016;173:3307-3326 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:100; fig 2 immunohistochemistry - paraffin section; human; 1:100; fig 3	Yang Y, Huycke M, Herman T, Wang X. Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer. Oncogene. 2016;35:5795-5806 pubmed publisher
	Martin M, Motolani A, Kim H, Collins A, Alipourgivi F, Jin J, et al. KDM2A Deficiency in the Liver Promotes Abnormal Liver Function and Potential Liver Damage. Biomolecules. 2023;13: pubmed publisher
	Chou C, Hung C, Chiu C, Tan X, Chen M, Chen C, et al. Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination. Nat Commun. 2023;14:6569 pubmed publisher
	Skibbe K, Brethack A, Sünderhauf A, Ragab M, Raschdorf A, Hicken M, et al. Colorectal Cancer Progression Is Potently Reduced by a Glucose-Free, High-Protein Diet: Comparison to Anti-EGFR Therapy. Cancers (Basel). 2021;13: pubmed publisher
	Davis T, Conradie D, Shridas P, de Beer F, Engelbrecht A, de Villiers W. Serum Amyloid A Promotes Inflammation-Associated Damage and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer. Cell Mol Gastroenterol Hepatol. 2021;12:1329-1341 pubmed publisher
	Fang Z, Kim H, Huang M, Chowdhury K, Li M, Liangpunsakul S, et al. Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal Kinases. Cell Mol Gastroenterol Hepatol. 2021;12:921-942 pubmed publisher
	Ma L, Gonzàlez Juncà A, Zheng Y, Ouyang H, Illa Bochaca I, Horst K, et al. Inflammation Mediates the Development of Aggressive Breast Cancer Following Radiotherapy. Clin Cancer Res. 2021;27:1778-1791 pubmed publisher
	Zhong X, Huang M, Kim H, Zhang Y, Chowdhury K, Cai W, et al. SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells. Cell Mol Gastroenterol Hepatol. 2020;10:341-364 pubmed publisher
	Chung K, Singh J, Lawres L, Dorans K, Garcia C, Burkhardt D, et al. Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma. Cell. 2020;181:832-847.e18 pubmed publisher
	Simon N, Antignani A, Hewitt S, Gadina M, Alewine C, Fitzgerald D. Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells. JCI Insight. 2019;4: pubmed publisher
	Sorrelle N, Ganguly D, Dominguez A, Zhang Y, Huang H, Dahal L, et al. Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues. J Immunol. 2019;202:292-299 pubmed publisher
	Tsai S, Hsu Y, Lee M, Huang H, Huang C, Tung Y. Effects of dextrose prolotherapy on contusion-induced muscle injuries in mice. Int J Med Sci. 2018;15:1251-1259 pubmed publisher
	Tarasco E, Pellegrini G, Whiting L, Lutz T. Phenotypical heterogeneity in responder and nonresponder male ApoE*3Leiden.CETP mice. Am J Physiol Gastrointest Liver Physiol. 2018;315:G602-G617 pubmed publisher
	Donzelli S, Milano E, Pruszko M, Sacconi A, Masciarelli S, Iosue I, et al. Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages. Breast Cancer Res. 2018;20:59 pubmed publisher
	Vallelian F, Schaer C, Deuel J, Ingoglia G, Humar R, Buehler P, et al. Revisiting the putative role of heme as a trigger of inflammation. Pharmacol Res Perspect. 2018;6:e00392 pubmed publisher
	Sanderlin E, Leffler N, Lertpiriyapong K, Cai Q, Hong H, Bakthavatchalu V, et al. GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:569-584 pubmed publisher

product information

Product Type :

Antibody

Product Name :

F4/80 Monoclonal Antibody (SP115)

Catalog # :

MA5-16363

Quantity :

500 uL

Price :

US 582.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Mouse

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50-1:100

Species :

Mouse

Clone :

SP115

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.

Immunogen :

Synthetic peptide derived from N-terminus of mouse F4/80 protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50-1:100

Aliases :

ADGRE1; Adhesion G protein-coupled receptor E1; Adhesion G protein-coupled receptor E2; cell surface glycoprotein EMR1; cell surface glycoprotein F4/80; DD7A5-7; EGF-like module containing, mucin-like, hormone receptor-like 1; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGF-TM7; Emr1; EMR1 hormone receptor; F4/80; Gpf480; Ly71; lymphocyte antigen 71; TM7LN3

more info or order :

Invitrogen product webpage