This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (SP35)
catalog :
MA5-16338
quantity :
500 uL
price :
US 616.00
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
SP35

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 3
Reference
Weichseldorfer M, Affram Y, Heredia A, Rikhtegaran Tehrani Z, Sajadi M, Williams S, et al. Combined cART including Tenofovir Disoproxil, Emtricitabine, and Dolutegravir has potent therapeutic effects in HIV-1 infected humanized mice. J Transl Med. 2021;19:453 pubmed publisher
Barber Axthelm I, Barber Axthelm V, Sze K, Zhen A, Suryawanshi G, CHEN I, et al. Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques. JCI Insight. 2021;6: pubmed publisher
Lossius A, Berents T, Saetre F, Nilsen H, Bradley M, Asad S, et al. Early transcriptional changes after UVB treatment in atopic dermatitis include inverse regulation of IL-36γ and IL-37. Exp Dermatol. 2021;30:249-261 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (SP35)
Catalog # :
MA5-16338
Quantity :
500 uL
Price :
US 616.00
Clonality :
Monoclonal
Purity :
Protein A/G
Host :
Rabbit
Reactivity :
Human
Applications :
Flow Cytometry: 1:20-1:100, Immunohistochemistry (Paraffin): 1:50
Species :
Human
Clone :
SP35
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Immunogen :
Synthetic peptide corresponding to internal region of human CD4.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:20-1:100, Immunohistochemistry (Paraffin): 1:50
Aliases :
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA