Bax Monoclonal Antibody (SP47) | Invitrogen MA5-16322 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bax Monoclonal Antibody (SP47)

catalog :

MA5-16322

quantity :

100 uL

price :

US 524.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SP47

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000	Li L, Wu W, Huang W, Hu G, Yuan W, Li W. NF-?B RNAi decreases the Bax/Bcl-2 ratio and inhibits TNF-?-induced apoptosis in human alveolar epithelial cells. Inflamm Res. 2013;62:387-97 pubmed publisher
immunoprecipitation; rat immunocytochemistry; rat western blot; rat	Yi X, Wang J, Seol D, Dong Z. Characterization of cell clones stably transfected with short form caspase-9: apoptotic resistance and Bcl-XL expression. Mol Cell Biochem. 2006;282:1-12 pubmed

product information

Product Type :

Antibody

Product Name :

Bax Monoclonal Antibody (SP47)

Catalog # :

MA5-16322

Quantity :

100 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:50

Species :

Human

Clone :

SP47

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.

Immunogen :

Synthetic peptide corresponding to internal region of human BAX protein.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50

Aliases :

apoptosis regulator BAX; Apoptosis regulator Bcl-X; Bax; Bax zeta; BAX-ALPHA; Bax-alpha protein; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2 associated X, apoptosis regulator; BCL2 like 1; BCL2-associated protein; Bcl-2-associated protein Bax; Bcl2-associated protein Bax; Bcl-2-associated X protein; BCL2-associated X protein; BCL2-associated X protein omega; BCL2L; BCL2L1; Bcl2-L-1; BCL2L4; Bcl2-L-4; BCL2-like 1; bcl-2-like protein 1; Bcl-2-like protein 4; BCLX; Bcl-X; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52

more info or order :

Invitrogen product webpage