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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
beta Tubulin Loading Control Monoclonal Antibody (BT7R)
catalog :
MA5-16308-1MG
quantity :
1 mg
price :
US 1152.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BT7R
reactivity :
human, mouse, rat, dogs, chicken, domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 57
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000; fig 4
Topalidou I, Cattin Ortolá J, Pappas A, Cooper K, Merrihew G, MacCoss M, et al. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. PLoS Genet. 2016;12:e1006074 pubmed publisher
  • western blot; rat; 1:5000; loading ...; fig 4a
Thierry M, Pasquis B, Buteau B, Fourgeux C, Dembele D, Leclère L, et al. Early adaptive response of the retina to a pro-diabetogenic diet: Impairment of cone response and gene expression changes in high-fructose fed rats. Exp Eye Res. 2015;135:37-46 pubmed publisher
Hosawi S, Humphries J, Coward R, Knight D, Humphries M, Lennon R. Global proteomic analysis of insulin receptor interactors in glomerular podocytes. Wellcome Open Res. 2020;5:202 pubmed publisher
Das R, Balmik A, Chinnathambi S. Melatonin Reduces GSK3β-Mediated Tau Phosphorylation, Enhances Nrf2 Nuclear Translocation and Anti-Inflammation. ASN Neuro. 2020;12:1759091420981204 pubmed publisher
Prieto Fernández E, Egia Mendikute L, Bosch A, García Del Río A, Jimenez Lasheras B, Antoñana Vildosola A, et al. Hypoxia Promotes Syndecan-3 Expression in the Tumor Microenvironment. Front Immunol. 2020;11:586977 pubmed publisher
Cheng Y, Cai J, Fu Y, Feng C, Hao Y, Wei Y. Royal jelly attenuates metabolic defects in a Drosophila mutant with elevated TORC1 activity. Biol Open. 2020;9: pubmed publisher
Kamand M, Ilieva M, Louise Forsberg S, Thomassen M, Meyer M, Fex Svenningsen A, et al. Derivation of induced pluripotent stem cells (SDUKIi003-A) from a 20-year-old male patient diagnosed with Asperger syndrome. Stem Cell Res. 2020;48:101974 pubmed publisher
Vallecillo Zúniga M, Rathgeber M, Poulson P, Hayes S, Luddington J, Gill H, et al. Treatment with galectin-1 improves myogenic potential and membrane repair in dysferlin-deficient models. PLoS ONE. 2020;15:e0238441 pubmed publisher
White A, Jean Alphonse F, Fang F, Pena K, Liu S, König G, et al. Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR. Proc Natl Acad Sci U S A. 2020;117:7455-7460 pubmed publisher
Bryson K, Garrido D, Esposito M, McLachlan G, Digard P, Schouler C, et al. Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung. Vet Res. 2020;51:2 pubmed publisher
Ni S, Ling Z, Wang X, Cao Y, Wu T, Deng R, et al. Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice. Nat Commun. 2019;10:5643 pubmed publisher
Wenta T, Rychlowski M, Jarzab M, Lipinska B. HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death. Cells. 2019;8: pubmed publisher
Ma E, Sahar N, Jeong M, Huh J. Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling. Front Physiol. 2019;10:1085 pubmed publisher
Lualdi M, Ronci M, Zilocchi M, Corno F, Turilli E, Sponchiado M, et al. Exploring the Mitochondrial Degradome by the TAILS Proteomics Approach in a Cellular Model of Parkinson's Disease. Front Aging Neurosci. 2019;11:195 pubmed publisher
Daher B, Parks S, Durivault J, Cormerais Y, Baidarjad H, Tambutte E, et al. Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival and tumor formation via nutrient and oxidative stresses. Cancer Res. 2019;: pubmed publisher
Monzón C, Garvin J. Claudin-19 mediates the effects of NO on the paracellular pathway in thick ascending limbs. Am J Physiol Renal Physiol. 2019;317:F411-F418 pubmed publisher
D Antona L, Dattilo V, Catalogna G, Scumaci D, Fiumara C, Musumeci F, et al. In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity. Transl Oncol. 2019;12:1045-1055 pubmed publisher
Zhang Z, Hunter L, Wu G, Maidstone R, Mizoro Y, Vonslow R, et al. Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion. FASEB J. 2019;33:6226-6238 pubmed publisher
Cormerais Y, Pagnuzzi Boncompagni M, Schrötter S, Giuliano S, Tambutte E, Endou H, et al. Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma. J Cell Mol Med. 2019;23:2711-2718 pubmed publisher
Kang S, Guan J, Tan H, Chu T, Thike A, Bernadó C, et al. Elevated WBP2 Expression in HER2-positive Breast Cancers Correlates with Sensitivity to Trastuzumab-based Neoadjuvant Therapy: A Retrospective and Multicentric Study. Clin Cancer Res. 2019;25:2588-2600 pubmed publisher
Li Q, Ran P, Zhang X, Guo X, Yuan Y, Dong T, et al. Downregulation of N-Acetylglucosaminyltransferase GCNT3 by miR-302b-3p Decreases Non-Small Cell Lung Cancer (NSCLC) Cell Proliferation, Migration and Invasion. Cell Physiol Biochem. 2018;50:987-1004 pubmed publisher
Lenin R, Nagy P, Gentry J, GANGARAJU R. Featured Article: Deterioration of visual function mediated by senescence-associated endoplasmic reticulum stress in inflammatory tie2-TNF mice. Exp Biol Med (Maywood). 2018;243:976-984 pubmed publisher
Suresh S, Chavalmane A, Pillai M, Ammanathan V, Vidyadhara D, Yarreiphang H, et al. Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective. Front Mol Neurosci. 2018;11:109 pubmed publisher
Cormerais Y, Massard P, Vucetic M, Giuliano S, Tambutte E, Durivault J, et al. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). J Biol Chem. 2018;293:2877-2887 pubmed publisher
Lee H, Im J, Won H, Kim J, Kim H, Kwon J, et al. Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia. Int J Mol Med. 2018;41:485-492 pubmed publisher
Topalidou I, Cooper K, Pereira L, Ailion M. Dopamine negatively modulates the NCA ion channels in C. elegans. PLoS Genet. 2017;13:e1007032 pubmed publisher
Rosado Olivieri E, Ramos Ortiz G, Hernández Pasos J, Díaz Balzac C, Vázquez Rosa E, Valentín Tirado G, et al. A START-domain-containing protein is a novel marker of nervous system components of the sea cucumber Holothuria glaberrima. Comp Biochem Physiol B Biochem Mol Biol. 2017;214:57-65 pubmed publisher
Cattin Ortolá J, Topalidou I, Dosey A, Merz A, Ailion M. The dense-core vesicle maturation protein CCCP-1 binds RAB-2 and membranes through its C-terminal domain. Traffic. 2017;18:720-732 pubmed publisher
Mi Y, Chen H, Guo N, Sun M, Zhao Z, Gao X, et al. Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior. Front Aging Neurosci. 2017;9:199 pubmed publisher
Nandi S, Mishra P. H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes. Sci Rep. 2017;7:3639 pubmed publisher
Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, et al. Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Nature. 2017;545:500-504 pubmed publisher
Lei Y, Tang L, Xie Y, Xianyu Y, Zhang L, Wang P, et al. Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer. Nat Commun. 2017;8:15130 pubmed publisher
Suresh S, Chavalmane A, Dj V, Yarreiphang H, Rai S, Paul A, et al. A novel autophagy modulator 6-Bio ameliorates SNCA/?-synuclein toxicity. Autophagy. 2017;13:1221-1234 pubmed publisher
Cormerais Y, Giuliano S, Lefloch R, Front B, Durivault J, Tambutte E, et al. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res. 2016;76:4481-92 pubmed publisher
Bernis M, Babila J, Breid S, Wüsten K, Wüllner U, Tamgüney G. Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein. Acta Neuropathol Commun. 2015;3:75 pubmed publisher
Severi I, Perugini J, Mondini E, Smorlesi A, Frontini A, Cinti S, et al. Opposite effects of a high-fat diet and calorie restriction on ciliary neurotrophic factor signaling in the mouse hypothalamus. Front Neurosci. 2013;7:263 pubmed publisher
Michaloglou C, Lehmann W, Martin T, Delaunay C, Hueber A, Barys L, et al. The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. PLoS ONE. 2013;8:e61916 pubmed publisher
Yeh C, Chen T, Wang Y, Lin Y, Fang S. Carvedilol treatment after myocardial infarct decreases cardiomyocytic apoptosis in the peri-infarct zone during cardioplegia-induced cardiac arrest. Shock. 2013;39:343-52 pubmed publisher
Hashimoto M, Enomoto M, Morales J, Kurebayashi N, Sakurai T, Hashimoto T, et al. Inositol 1,4,5-trisphosphate receptor regulates replication, differentiation, infectivity and virulence of the parasitic protist Trypanosoma cruzi. Mol Microbiol. 2013;87:1133-50 pubmed publisher
Barr J, Munyikwa M, Frazier E, Hinton S. The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1. FEBS J. 2013;280:273-84 pubmed publisher
Yeh C, Chen T, Wang Y, Lin Y, Fang S. MicroRNA-27a regulates cardiomyocytic apoptosis during cardioplegia-induced cardiac arrest by targeting interleukin 10-related pathways. Shock. 2012;38:607-14 pubmed publisher
Huang Y, Wu M, Pan S, Su W, Chen Y, Wu L. STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production. Angiogenesis. 2013;16:207-22 pubmed publisher
Hsieh W, Lin Y, Tsai C, Wang T, Chen T, Pang J. Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes. J Dermatol Sci. 2012;67:140-6 pubmed publisher
Singla A, Moons D, Snider N, Wagenmaker E, Jayasundera V, Omary M. Oxidative stress, Nrf2 and keratin up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria. Hepatology. 2012;56:322-31 pubmed publisher
Shock L, Thakkar P, Peterson E, Moran R, Taylor S. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011;108:3630-5 pubmed publisher
Thuillier R, Mazer M, Manku G, Boisvert A, Wang Y, Culty M. Interdependence of platelet-derived growth factor and estrogen-signaling pathways in inducing neonatal rat testicular gonocytes proliferation. Biol Reprod. 2010;82:825-36 pubmed publisher
Kaur M, Mandair R, Agarwal R, Agarwal C. Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells. Nutr Cancer. 2008;60 Suppl 1:2-11 pubmed publisher
Zhou Y, Uddin S, Zimmerman T, Kang J, Ulaszek J, Wickrema A. Growth control of multiple myeloma cells through inhibition of glycogen synthase kinase-3. Leuk Lymphoma. 2008;49:1945-53 pubmed publisher
Townley A, Feng Y, Schmidt K, Carter D, Porter R, Verkade P, et al. Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development. J Cell Sci. 2008;121:3025-34 pubmed publisher
Yang Y, Zhang L, Wei Y, Wang H, Fukuma M, Xu H, et al. Neural differentiation arrest in embryonal carcinoma cells with forced expression of EWS-FLI1. J Neurooncol. 2008;90:141-50 pubmed publisher
Cangi M, Piccinin S, Pecciarini L, Talarico A, Dal Cin E, Grassi S, et al. Constitutive overexpression of CDC25A in primary human mammary epithelial cells results in both defective DNA damage response and chromosomal breaks at fragile sites. Int J Cancer. 2008;123:1466-71 pubmed publisher
Aicher D, Urbich C, Zeiher A, Dimmeler S, Schäfers H. Endothelial nitric oxide synthase in bicuspid aortic valve disease. Ann Thorac Surg. 2007;83:1290-4 pubmed
Kovar J, Neubauerova J, Cimburova M, Truksa J, Balusikova K, Horak J. Stimulation of non-transferrin iron uptake by iron deprivation in K562 cells. Blood Cells Mol Dis. 2006;37:95-9 pubmed
Rangwala R, Banine F, Borg J, Sherman L. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. J Biol Chem. 2005;280:11790-7 pubmed
Petermann A, Pippin J, Durvasula R, Pichler R, Hiromura K, Monkawa T, et al. Mechanical stretch induces podocyte hypertrophy in vitro. Kidney Int. 2005;67:157-66 pubmed
Ferrari Toninelli G, Paccioretti S, Francisconi S, Uberti D, Memo M. TorsinA negatively controls neurite outgrowth of SH-SY5Y human neuronal cell line. Brain Res. 2004;1012:75-81 pubmed
Aicher A, Heeschen C, Mohaupt M, Cooke J, Zeiher A, Dimmeler S. Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions. Circulation. 2003;107:604-11 pubmed
product information
Product Type :
Antibody
Product Name :
beta Tubulin Loading Control Monoclonal Antibody (BT7R)
Catalog # :
MA5-16308-1MG
Quantity :
1 mg
Price :
US 1152.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Canine, Chicken, Human, Mouse, Non-human primate, Rabbit, Rat
Applications :
ELISA: Assay-dependent, Flow Cytometry: 1 µg/test, Immunocytochemistry: 1:50-1:500, Immunohistochemistry (Paraffin): 1:10-1:500, Western Blot: 1:2,000-1:5,000
Species :
Canine, Chicken, Human, Mouse, Non-human primate, Rabbit, Rat
Clone :
BT7R
Isotype :
IgG2a
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintenance. Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules.Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting.
Immunogen :
KLH conjugated peptide of the N-terminus of Beta-Tubulin.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Flow Cytometry: 1 µg/test, Immunocytochemistry: 1:50-1:500, Immunohistochemistry (Paraffin): 1:10-1:500, Western Blot: 1:2,000-1:5,000
Aliases :
2310057H16Rik; 2810484G07Rik; 3200002H15Rik; AA408537; AI325297; AI596182; B130022C14Rik; bA631M21.2; BB220206; beta 5-tubulin; beta Ib tubulin; beta tubulin; beta tubulin 1; beta-4; beta-4 tubulin; beta-4-tubulin; beta-5; beta-5 tubulin; beta5-tubulin; betaIII-tubulin; beta-tubulin; beta-tubulin class-III; Beta-tubulin class-V; beta-tubulin class-VI; Beta-tubulin isotype I; c(beta)7 tubulin; CDCBM; CDCBM1; CDCBM5; CDCBM6; CFEOM3; CFEOM3A; class I beta tubulin; Class I beta-tubulin; class IIa beta-tubulin; class III beta-tubulin; class IVa beta-tubulin; class V beta tubulin; class V beta-tubulin; CSCSC1; dJ40E16.7; dystonia 4, torsion (autosomal dominant); DYT4; FEOM3; HSA10p15 beta-tubulin 4Q; HsT1601; hypothetical protein LOC540236; hypothetical protein LOC550458; I79_000194; I79_012097; LOC100349792; LOC100761889; LOW QUALITY PROTEIN: tubulin beta-6 chain; M(beta)1; M(beta)2; M(beta)3; M(beta)4; M(beta)5; M(beta)6; M40; M40 antibody; MGC128415 protein; MGC137802 protein; neuron-specific class III beta-tubulin; OK/SW-cl.56; OOMD; OOMD2; RGD1305887; si:ch211-122i22.4; si:ch211-9a18.2; Tubb; tubb beta-5; tubb.L; Tubb1; TUBB2; Tubb2a; tubb2a {ECO:0000250; Tubb3; TUBB4; TUBB4A; tubb5; TUBB-5; TUBB6; TUBB8; Tubulin 5 beta; tubulin beta; tubulin beta 1 class VI; tubulin beta 2A class IIa; tubulin beta 3 class III; tubulin beta 4'; tubulin beta 4A class IVa; tubulin beta 6 class V; tubulin beta 8 class VIII; Tubulin beta chain; tubulin beta class I; tubulin beta class I L homeolog; Tubulin beta class IIa; Tubulin beta class V; tubulin beta MGC4083; tubulin beta-1; tubulin beta-1 chain; tubulin beta-1 chain-like; tubulin beta-2A chain; tubulin beta-2B chain; tubulin beta-3 chain; Tubulin beta-4 chain; tubulin beta-4A chain; Tubulin beta-5 chain; tubulin beta-5 chain; tubulin beta-6 chain; tubulin beta-6 chain; Tubulin beta-7 chain; tubulin beta-8 chain; Tubulin beta-III; tubulin, beta 1 class VI; tubulin, beta 2; tubulin, beta 2A; tubulin, beta 2A class IIA; tubulin, beta 3; tubulin, beta 3 class III; tubulin, beta 4; tubulin, beta 4 class IVa; tubulin, beta 4A class IVa; tubulin, beta 5; tubulin, beta 5 class I; tubulin, beta 6 class V; tubulin, beta class I; tubulin, beta family 1; tubulin, beta polypeptide; tubulin, beta polypeptide 2; tubulin, beta, 3; tubulin, beta, 4; tubulin, beta, 5; uncharacterized protein LOC550458; UniProtKB:Q7TMM9}; Unknown (protein for MGC:134115); unnamed protein product; XELAEV_18039222mg; XLOT; zbetaI; zgc:112515
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA