This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Dectin 2 Monoclonal Antibody (3D1)
catalog :
MA5-16250
quantity :
100 ug
price :
US 464.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3D1

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
Dectin 2 Monoclonal Antibody (3D1)
Catalog # :
MA5-16250
Quantity :
100 ug
Price :
US 464.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Non-human primate
Applications :
Flow Cytometry: 0.5 ug/5x10^5 cells, Immunohistochemistry (Paraffin): 1:200, Western Blot: 2-5 ug/mL
Species :
Human, Non-human primate
Clone :
3D1
Isotype :
IgG3, kappa
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages and inflammatory monocytes. It is a type II membrane receptor, with a short cytoplasmic tail, and a C-terminal C-type lectin domain. Dectin-2 is a receptor with specificity for high mannose structures and mediates cytokine production from DC and other antigen presenting cells. Though, Dectin-2 has no obvious signaling motifs attached to CP tail, reports indicate that Dectin-2 employs FcRg for internalization and to activate NF-kappaB pathway for cytokine production. Though it shares only 20-25% of homology with Dectin-1, it functions similarly as pattern recognition receptor (PRR) for fungal infections, to activate both innate (Syk-CARD9 innate signaling pathway) and adaptive immune responses (by activation of DC) to fungal infections. Thus Dectin-2 is a connector molecule of both innate and adaptive immunity functioning at DC level.
Immunogen :
A blend of two peptides made to amino acids 44-63 and 90-106 of human Dectin-2.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/5x10^5 cells, Immunohistochemistry (Paraffin): 1:200, Western Blot: 2-5 ug/mL
Aliases :
Clec4n; CLEC6A; Clec6a-ps1; CLECSF10; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10; C-type lectin domain family 4, member n; C-type lectin domain family 6 member A; C-type lectin domain family 6, member A; C-type lectin domain family 6, member A, pseudogene 1; C-type lectin superfamily member 10; DC-associated C-type lectin 2; dectin 2; DECTIN2; dectin-2; Dectin-2p; Dendritic cell-associated C-type lectin 2; natural killer complex lectin; Nkcl
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA