This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TLR7 Monoclonal Antibody (4G6)
catalog :
MA5-16247
quantity :
100 ug
price :
US 510.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4G6

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunocytochemistry, flow cytometry
citations: 3
Reference
Hegewald A, Breitwieser K, Ottinger S, Mobarrez F, Korotkova M, Rethi B, et al. Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis. Front Immunol. 2020;11:585282 pubmed publisher
Deeba E, Lambrianides A, Pantzaris M, Krashias G, Christodoulou C. The expression profile of virus-recognizing toll-like receptors in natural killer cells of Cypriot multiple sclerosis patients. BMC Res Notes. 2020;13:460 pubmed publisher
van Haren S, Dowling D, Foppen W, Christensen D, Andersen P, Reed S, et al. Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization. J Immunol. 2016;197:4413-4424 pubmed
product information
Product Type :
Antibody
Product Name :
TLR7 Monoclonal Antibody (4G6)
Catalog # :
MA5-16247
Quantity :
100 ug
Price :
US 510.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 1-2 ug/1x10^6 cells, Immunocytochemistry: 1:500-1:5,000, Western Blot: 10 ug/mL
Species :
Human, Mouse
Clone :
4G6
Isotype :
IgG1, kappa
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Immunogen :
A partial human TLR7 recombinant protein (amino acids 562-839).
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1-2 ug/1x10^6 cells, Immunocytochemistry: 1:500-1:5,000, Western Blot: 10 ug/mL
Aliases :
RGD1563357; RP23-139P21.3; Tlr7; TLR7-like; toll like receptor 7; toll-like receptor 7; toll-like receptor 7-like; UNQ248/PRO285
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA