This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TLR5 Monoclonal Antibody (19D759.2), PE
catalog :
MA5-16241
quantity :
100 uL
price :
US 491.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
19D759.2

The same clone is also sold as:
reactivity :
human, mouse, dogs
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
TLR5 Monoclonal Antibody (19D759.2), PE
Catalog # :
MA5-16241
Quantity :
100 uL
Price :
US 491.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Canine, Human, Mouse
Applications :
Flow Cytometry: 1 uL per million cells, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: Assay-Dependent
Species :
Canine, Human, Mouse
Clone :
19D759.2
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark
Description :
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. TLR5 also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR5 protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has a unique TLR5 haplotype and a lower expression of TRL5. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response.
Immunogen :
KLH-conjugated synthetic peptide corresponding to a portion of human TLR5 between amino acids 700-800
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 uL per million cells, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
FLJ10052; MELIOS; MGC126430; MGC126431; RP11-239E10.1; SLE1; SLEB1; systemic lupus erythematosus susceptibility 1; TIL3; Tlr5; toll like receptor 5; Toll/interleukin-1 receptor-like protein 3; toll-like receptor 5
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA