TLR4 Monoclonal Antibody (76B357.1) | Invitrogen MA5-16216 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TLR4 Monoclonal Antibody (76B357.1)

catalog :

MA5-16216

quantity :

100 ug

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

76B357.1

reactivity :

human, mouse, rat, bovine, pigs

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, dot blot

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 6b	Hong J, Zhang M, He Y, Jin Y, He Q, Zhang Y, et al. Qinghao-Biejia Herb Pair Alleviates Pristane-Induced Lupus-Like Disease and Associated Renal and Aortic Lesions in ApoE-/- Mice. Front Pharmacol. 2022;13:897669 pubmed publisher
flow cytometry; human; fig 1c	van Haren S, Dowling D, Foppen W, Christensen D, Andersen P, Reed S, et al. Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization. J Immunol. 2016;197:4413-4424 pubmed
western blot; human; 1:1000; fig 5b	Shi D, Shi G, Xie J, Du X, Yang H. MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis. Mol Cells. 2016;39:611-8 pubmed publisher
	Liu Z, Sammani S, Barber C, Kempf C, Li F, Yang Z, et al. An eNAMPT-neutralizing mAb reduces post-infarct myocardial fibrosis and left ventricular dysfunction. Biomed Pharmacother. 2024;170:116103 pubmed publisher
	Scharmacher J, Wartenberg M, Sauer H. The pro-inflammatory signature of lipopolysaccharide in spontaneous contracting embryoid bodies differentiated from mouse embryonic stem cells. J Cell Mol Med. 2023;27:2045-2058 pubmed publisher
	Roth C, Craveiro R, Niederau C, Malyaran H, Neuss S, Jankowski J, et al. Mechanical Compression by Simulating Orthodontic Tooth Movement in an In Vitro Model Modulates Phosphorylation of AKT and MAPKs via TLR4 in Human Periodontal Ligament Cells. Int J Mol Sci. 2022;23: pubmed publisher
	Li W, Wang T, Huang W, Li F, Quan J, Shi G, et al. Malassezia globosa Activates NLRP3 Inflammasome in Human Sebocytes. J Invest Dermatol. 2022;142:2042-2046.e11 pubmed publisher
	Tao W, Fu T, He Z, Zhou H, Hong Y. Immunomodulatory effects of Radix isatidis polysaccharides in vitro and in vivo. Exp Ther Med. 2021;22:1405 pubmed publisher
	Tidu F, De Zuani M, Jose S, Bendickova K, Kubala L, Caruso F, et al. NFAT signaling in human mesenchymal stromal cells affects extracellular matrix remodeling and antifungal immune responses. iScience. 2021;24:102683 pubmed publisher
	Seguella L, Pesce M, Capuano R, Casano F, Pesce M, Corpetti C, et al. High-fat diet impairs duodenal barrier function and elicits glia-dependent changes along the gut-brain axis that are required for anxiogenic and depressive-like behaviors. J Neuroinflammation. 2021;18:115 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TLR4 Monoclonal Antibody (76B357.1)

Catalog # :

MA5-16216

Quantity :

100 ug

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Human, Mammalia, Mouse, Porcine, Rat

Applications :

ChIP Assay: 1:10-1:500, Dot Blot: Assay-Dependent, ELISA: 0.5 ug, Flow Cytometry: 1:10-1:500, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Frozen): 1:500, Immunohistochemistry (Paraffin): 5 ug/mL, In vitro Assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: 1-3 ug/mL

Species :

Bovine, Human, Mammalia, Mouse, Porcine, Rat

Clone :

76B357.1

Isotype :

IgG2b, kappa

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

Immunogen :

Synthetic peptide (aa 100-200 of human TLR4, isoform C, LPEYFSNLTNLEHL) of TLR4/CD284 protein.

Format :

Liquid

Applications w/Dilutions :

Aliases :

ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein

more info or order :

Invitrogen product webpage