product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TLR4/MD-2 Complex Monoclonal Antibody (MTS510)
catalog :
MA5-16210
quantity :
100 ug
price :
US 474.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MTS510
reactivity :
human, mouse
application :
immunocytochemistry, immunoprecipitation, flow cytometry, blocking or activating experiments
more info or order :
citations: 8
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...
Schweighoffer E, Nys J, Vanes L, Smithers N, Tybulewicz V. TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK. J Exp Med. 2017;214:1269-1280 pubmed publisher
  • blocking or activating experiments; human; loading ...; fig 4c
Horvatinovich J, Grogan E, Norris M, Steinkasserer A, Lemos H, Mellor A, et al. Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes. J Immunol. 2017;198:2286-2301 pubmed publisher
  • flow cytometry; mouse; fig 6d
Maharaj K, Que N, Hong F, Huck J, Gill S, Wu S, et al. Exploring the Functional Complementation between Grp94 and Hsp90. PLoS ONE. 2016;11:e0166271 pubmed publisher
Yan N, Wen D, Zhao Y, Xu S. Epimedium sagittatum inhibits TLR4/MD-2 mediated NF-κB signaling pathway with anti-inflammatory activity. BMC Complement Altern Med. 2018;18:303 pubmed publisher
Li Q, Dai C, Xue R, Wang P, Chen L, Han Y, et al. S100A4 Protects Myeloid-Derived Suppressor Cells from Intrinsic Apoptosis via TLR4-ERK1/2 Signaling. Front Immunol. 2018;9:388 pubmed publisher
Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi Miyamoto T, et al. Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex. J Biol Chem. 2017;292:15378-15394 pubmed publisher
Boehmer E, Meehan M, Cutro B, Kovacs E. Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev. 2005;126:1305-13 pubmed
Andonegui G, Kerfoot S, McNagny K, Ebbert K, Patel K, Kubes P. Platelets express functional Toll-like receptor-4. Blood. 2005;106:2417-23 pubmed
product information
Product Type :
Antibody
Product Name :
TLR4/MD-2 Complex Monoclonal Antibody (MTS510)
Catalog # :
MA5-16210
Quantity :
100 ug
Price :
US 474.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1-2 ug per million cells, Immunocytochemistry: Assay-Dependent, Immunoprecipitation: 1:10-1:500
Species :
Mouse
Clone :
MTS510
Isotype :
IgG2a, kappa
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
Immunogen :
Ba/F3 cell line expressing mouse TLR4 and MD-2
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1-2 ug per million cells, Immunocytochemistry: Assay-Dependent, Immunoprecipitation: 1:10-1:500
Aliases :
ARMD10; CD284; Esop1; ESOP-1; hToll; lipopolysaccharide response; Lps; Ly87; Ly96; Ly-96; Lymphocyte antigen 96; Md2; MD-2; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; Toll-like receptor 4
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA