TLR2 Monoclonal Antibody (TL2.1) | Invitrogen MA5-16200 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TLR2 Monoclonal Antibody (TL2.1)

catalog :

MA5-16200

quantity :

100 ug

price :

US 425.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TL2.1

reactivity :

human, mouse, rat, dogs, domestic rabbit

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, dot blot, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 6	Bzowska M, Nogieć A, Bania K, Zygmunt M, Zarebski M, Dobrucki J, et al. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages. J Leukoc Biol. 2017;102:763-774 pubmed publisher
flow cytometry; human; fig 1 immunohistochemistry; human; loading ...; fig 2	Mitterreiter J, Ouwendijk W, van Velzen M, van Nierop G, Osterhaus A, Verjans G. Satellite glial cells in human trigeminal ganglia have a broad expression of functional Toll-like receptors. Eur J Immunol. 2017;47:1181-1187 pubmed publisher
flow cytometry; human; loading ...; fig 1e	Sadeghi K, Wisgrill L, Wessely I, Diesner S, Schuller S, Dürr C, et al. GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes. PLoS ONE. 2016;11:e0162667 pubmed publisher
flow cytometry; human; loading ...	Gren S, Janciauskiene S, Sandeep S, Jonigk D, Kvist P, Gerwien J, et al. The protease inhibitor cystatin C down-regulates the release of IL-? and TNF-? in lipopolysaccharide activated monocytes. J Leukoc Biol. 2016;100:811-822 pubmed
blocking or activating experiments; human; fig 6	SnÃ¤ll J, LinnÃ©r A, Uhlmann J, Siemens N, Ibold H, Janos M, et al. Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release. Sci Rep. 2016;6:21288 pubmed publisher
	Giannakopoulos S, Strange D, Jiyarom B, Abdelaal O, Bradshaw A, Nerurkar V, et al. In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury. PLoS Pathog. 2023;19:e1011409 pubmed publisher
	Fan Y, Yang L, Wei Q, Ding Y, Tang Z, Tan P, et al. Toll-like receptor 10 (TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells. Asian J Androl. 2019;21:393-399 pubmed publisher
	Nogueira A, Nokhbehsaim M, Eick S, Bourauel C, Jager A, Jepsen S, et al. Biomechanical loading modulates proinflammatory and bone resorptive mediators in bacterial-stimulated PDL cells. Mediators Inflamm. 2014;2014:425421 pubmed publisher
	Nazli A, Kafka J, Ferreira V, Anipindi V, Mueller K, Osborne B, et al. HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium. J Immunol. 2013;191:4246-58 pubmed publisher
	Al ofi E, Coffelt S, Anumba D. Monocyte subpopulations from pre-eclamptic patients are abnormally skewed and exhibit exaggerated responses to Toll-like receptor ligands. PLoS ONE. 2012;7:e42217 pubmed publisher
	Balachandran P, Pugh N, Ma G, Pasco D. Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice. Int Immunopharmacol. 2006;6:1808-14 pubmed

product information

Product Type :

Antibody

Product Name :

TLR2 Monoclonal Antibody (TL2.1)

Catalog # :

MA5-16200

Quantity :

100 ug

Price :

US 425.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Rabbit, Rat

Applications :

Dot Blot: Assay-Dependent, ELISA: Assay-Dependent, Flow Cytometry: 1 ug per million cells, Functional Assay: Assay-Dependent, Immunocytochemistry: 1:10-1:500, Immunoprecipitation: 2-5 ug, In vitro Assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: 1 - 2 ug/mL

Species :

Canine, Human, Mouse, Rabbit, Rat

Clone :

TL2.1

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

Immunogen :

CHO cells transfected with human TLR2 cDNA

Format :

Liquid

Applications w/Dilutions :

Aliases :

CD282; Ly105; TIL4; Tlr2; TLR-2; toll like receptor 2; toll/interleukin-1 receptor-like protein 4; Toll-like receptor; toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; toll-like-receptor 2, exon 1a_; Toll-like-receptor, exon 1b; Toll-like-receptor, exon 1b_; Toll-like-receptor2, exon 1a

more info or order :

Invitrogen product webpage