This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TLR3 Monoclonal Antibody (40C1285.6)
catalog :
MA5-16184
quantity :
100 ug
price :
US 484.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
40C1285.6

The same clone is also sold as:
reactivity :
human, mouse, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section
citations: 2
Reference
Tucker M, Yu W, Menden H, Xia S, Schreck C, Gibson M, et al. IRF7 and UNC93B1 variants in an infant with recurrent herpes simplex virus infection. J Clin Invest. 2023;133: pubmed publisher
Mielcarska M, Bossowska Nowicka M, Gregorczyk Zboroch K, Wy x17c ewski Z, Szulc D x105 browska L, Giery x144 ska M, et al. Syk and Hrs Regulate TLR3-Mediated Antiviral Response in Murine Astrocytes. Oxid Med Cell Longev. 2019;2019:6927380 pubmed publisher
product information
Product Type :
Antibody
Product Name :
TLR3 Monoclonal Antibody (40C1285.6)
Catalog # :
MA5-16184
Quantity :
100 ug
Price :
US 484.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Canine, Human, Mouse
Applications :
Flow Cytometry: 2-4 ug per million cells, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Paraffin): 1:10-1:500, Neutralization: Assay-Dependent, Western Blot: 1-3 ug/mL
Species :
Canine, Human, Mouse
Clone :
40C1285.6
Isotype :
IgG1, kappa
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
TLR3 (Toll-like receptor 3, CD283) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. Further, TLR3 may play a role in host defense against viruses, and the use of alternative polyadenylation sites to generate different length transcripts has been noted for the TLR3 gene. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kB. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.
Immunogen :
A synthetic peptide corresponding to amino acids 55-85 of human TLR3 was used as immunogen.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 2-4 ug per million cells, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Paraffin): 1:10-1:500, Neutralization: Assay-Dependent, Western Blot: 1-3 ug/mL
Aliases :
AI957183; CD283; IIAE2; TLR 3; TLR3; TLR-3; toll like receptor 3; toll-like receptor 3; toll-like receptor 3 variant 1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA