This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
DNMT3A Monoclonal Antibody (64B1446)
catalog :
MA5-16171
quantity :
100 ug
price :
US 524.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
64B1446

The same clone is also sold as:
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 2
Reference
Liu Z, Lu T, Ma L, Zhang Y, Li D. DNA demethylation of promoter region orchestrates SPI-1-induced ADAMTS-5 expression in articular cartilage of osteoarthritis mice. J Cell Physiol. 2024;239:e31170 pubmed publisher
Wang X, Zhang J, Liao Y, Jin Y, Yu X, Li H, et al. DNMT1-Mediated DNA Methylation Targets CDKN2B to Promote the Repair of Retinal Ganglion Cells in Streptozotocin-Induced Mongolian Gerbils during Diabetic Retinopathy. Comput Math Methods Med. 2022;2022:9212116 pubmed publisher
product information
Product Type :
Antibody
Product Name :
DNMT3A Monoclonal Antibody (64B1446)
Catalog # :
MA5-16171
Quantity :
100 ug
Price :
US 524.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
ChIP Assay: Assay-Dependent, Flow Cytometry: 1 ug per million cells, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 2 ug/mL
Species :
Human, Mouse, Rat
Clone :
64B1446
Isotype :
IgG1, kappa
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
Immunogen :
Bacteria expressed recombinant mouse Dnmt3a.
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: Assay-Dependent, Flow Cytometry: 1 ug per million cells, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 2 ug/mL
Aliases :
AU015806; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA (cytosine-5)-methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase 3 alpha; DNA methyltransferase 3A; DNA methyltransferase HsaIIIA; DNA methyltransferase MmuIIIA; DNA MTase HsaIIIA; DNA MTase MmuIIIA; Dnmt3a; DNMT3A2; M.HsaIIIA; MmuIIIA; TBRS; W91664
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA