DUX4 Monoclonal Antibody (P4H2) | Invitrogen MA5-16147 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DUX4 Monoclonal Antibody (P4H2)

catalog :

MA5-16147

quantity :

100 µL

price :

US 430

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

P4H2

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:200; fig 2B	Siegele B, Roberts J, Black J, Rudzinski E, Vargas S, Galambos C. DUX4 Immunohistochemistry Is a Highly Sensitive and Specific Marker for CIC-DUX4 Fusion-positive Round Cell Tumor. Am J Surg Pathol. 2017;41:423-429 pubmed publisher
	Ko J, Marusic Z, Azzato E, Farkas D, Van Arnam J, Seiwerth S, et al. Superficial sarcomas with CIC rearrangement are aggressive neoplasms: A series of eight cases. J Cutan Pathol. 2020;47:509-516 pubmed publisher

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product information

Product Type :

Antibody

Product Name :

DUX4 Monoclonal Antibody (P4H2)

Catalog # :

MA5-16147

Quantity :

100 µL

Price :

US 430

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-Dependent, Immunocytochemistry: 1:100-1:200, Immunohistochemistry (Frozen): 1:100-1:200, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 0.5-2.0 µg/mL

Species :

Human

Clone :

P4H2

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein.

Immunogen :

Synthetic peptide corresponding to the C-terminal of human DUX4.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Immunocytochemistry: 1:100-1:200, Immunohistochemistry (Frozen): 1:100-1:200, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 0.5-2.0 µg/mL

Aliases :

AW822073; double homeobox; double homeobox 4; double homeobox 4-like; double homeobox B-like 1; double homeobox protein 10; Double homeobox protein 4; double homeobox protein 4/10; Dux; DUX10; Dux4; DUX4L; Duxbl; Duxbl1; EG664783; homeobox protein; RGD1311053

more info or order :

Invitrogen product webpage