TERT Monoclonal Antibody (2C4) | Invitrogen MA5-16034 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TERT Monoclonal Antibody (2C4)

catalog :

MA5-16034

quantity :

100 µL

price :

US 450.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2C4

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:150; loading ...; fig 1	Carkić J, Nikolic N, Radojevic Skodric S, Kuzmanovic Pficer J, Brajović G, Antunović M, et al. The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma. J Oral Sci. 2016;58:449-458 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 1c	Endorf E, Qing H, Aono J, Terami N, Doyon G, Hyzny E, et al. Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes. Arterioscler Thromb Vasc Biol. 2017;37:301-311 pubmed publisher
flow cytometry; human; 1:200; loading ...	Suen H, Brown R, Yang S, Weatherburn C, Ho P, Woodland N, et al. Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade. Leukemia. 2016;30:1716-24 pubmed publisher
	Liu Y, Hall B, Lwin N, Teo E, Yam G, Hipsley A, et al. Tissue Responses and Wound Healing following Laser Scleral Microporation for Presbyopia Therapy. Transl Vis Sci Technol. 2020;9:6 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TERT Monoclonal Antibody (2C4)

Catalog # :

MA5-16034

Quantity :

100 µL

Price :

US 450.00

Clonality :

Monoclonal

Purity :

IgM

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ChIP Assay: Assay-Dependent, Flow Cytometry: 1:50-1:200, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50, Immunoprecipitation: 1:10-1:500, Western Blot: 1:500

Species :

Human, Mouse, Rat

Clone :

2C4

Isotype :

IgM

Storage :

-20°C or -80°C if preferred

Description :

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Immunogen :

Full-length recombinant hTERT from insect cells.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: Assay-Dependent, Flow Cytometry: 1:50-1:200, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50, Immunoprecipitation: 1:10-1:500, Western Blot: 1:500

Aliases :

CMM9; DKCA2; DKCB4; EST2; HEST2; hTERT; hTRT; PFBMFT1; RGD:70494}; TCS1; Telomerase catalytic subunit; telomerase reverse transcriptase; telomerase reverse transcriptase beta; telomerase-associated protein 2; TERT; tert {ECO:0000312; TP2; TR; TRT

more info or order :

Invitrogen product webpage