TERT Monoclonal Antibody (2D8) | Invitrogen MA5-16033 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TERT Monoclonal Antibody (2D8)

catalog :

MA5-16033

quantity :

100 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D8

The same clone is also sold as:

Novus Biologicals: NB100-297
OriGene: TA301587

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 2

Reference
Garrido Castillo L, Anract J, Delongchamps N, Huillard O, Benmohamed F, Decina A, et al. Polyploid Giant Cancer Cells Are Frequently Found in the Urine of Prostate Cancer Patients. Cancers (Basel). 2023;15: pubmed publisher
Potharaju M, Mathavan A, Mangaleswaran B, Patil S, John R, Ghosh S, et al. Clinicopathological Analysis of HIF-1alpha and TERT on Survival Outcome in Glioblastoma Patients: A Prospective, Single Institution Study. J Cancer. 2019;10:2397-2406 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TERT Monoclonal Antibody (2D8)

Catalog # :

MA5-16033

Quantity :

100 uL

Price :

US 524.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1:50-1:200, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Frozen): 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500-1:1,000

Species :

Human

Clone :

2D8

Isotype :

IgM

Storage :

-20 C or -80 C if preferred

Description :

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Immunogen :

Full-length recombinant hTERT from insect cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:50-1:200, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Frozen): 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500-1:1,000

Aliases :

CMM9; DKCA2; DKCB4; EST2; HEST2; hTERT; hTRT; PFBMFT1; RGD:70494}; TCS1; Telomerase catalytic subunit; telomerase reverse transcriptase; telomerase reverse transcriptase beta; telomerase-associated protein 2; TERT; tert {ECO:0000312; TP2; TR; TRT