Ku80 Monoclonal Antibody (5C5) | Invitrogen MA5-15873 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ku80 Monoclonal Antibody (5C5)

catalog :

MA5-15873

quantity :

100 µL

price :

US 510.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5C5

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig s9a	Nieborowska Skorska M, Sullivan K, Dasgupta Y, Podszywalow Bartnicka P, Hoser G, Maifrede S, et al. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. J Clin Invest. 2017;127:2392-2406 pubmed publisher
	Tay H, André H, Chrysostomou V, Adusumalli S, Guo J, Ren X, et al. Photoreceptor laminin drives differentiation of human pluripotent stem cells to photoreceptor progenitors that partially restore retina function. Mol Ther. 2023;31:825-846 pubmed publisher
	Panhale A, Richter F, Ramirez F, Shvedunova M, Manke T, Mittler G, et al. CAPRI enables comparison of evolutionarily conserved RNA interacting regions. Nat Commun. 2019;10:2682 pubmed publisher
	Iuchi S, Paulo J. Lysine-specific demethylase 2A enhances binding of various nuclear factors to CpG-rich genomic DNAs by action of its CXXC-PHD domain. Sci Rep. 2019;9:5496 pubmed publisher
	Maifrede S, Nieborowska Skorska M, Sullivan K, Dasgupta Y, Podszywalow Bartnicka P, Le B, et al. Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors. Blood. 2018;: pubmed publisher
	Maifrede S, Martin K, Podszywalow Bartnicka P, Sullivan Reed K, Langer S, Nejati R, et al. IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors. Mol Cancer Res. 2017;15:967-972 pubmed publisher

image

image 1 :

Immunohistochemical analysis of paraffin-embedded human tonsil tissues (left) and human colon cancer tissues (right) using MA5-15873 anti-XRCC5 antibody with DAB staining.

product information

Product Type :

Antibody

Product Name :

Ku80 Monoclonal Antibody (5C5)

Catalog # :

MA5-15873

Quantity :

100 µL

Price :

US 510.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: 1:10,000, Flow Cytometry: 1:200-1:400, Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 1:500-1:2,000

Species :

Human, Mouse

Clone :

5C5

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Immunogen :

Purified recombinant fragment of human XRCC5 expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:10,000, Flow Cytometry: 1:200-1:400, Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 1:500-1:2,000

Aliases :

86 kDa subunit of Ku antigen; AI314015; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; FLJ39089; G22p2; HGNC:12833; KARP1; KARP-1; Ku autoantigen; ku autoantigen protein p86 homolog; Ku autoantigen, 80kD); Ku autoantigen, 80kDa; Ku p80; Ku80; Ku-80; Ku86; Ku-86; Ku86 autoantigen related protein 1; KUB2; Kup80; Lupu; lupus; lupus Ku autoantigen protein p86; NFIV; nuclear factor IV; OTTHUMP00000164061; OTTHUMP00000206791; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa); X-ray repair cross complementation (double-strand-break rejoining; X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD); X-ray repair cross complementing 5; X-ray repair cross-complementing protein 5; Xrcc5

more info or order :

Invitrogen product webpage