CrkL Monoclonal Antibody (5E12) | Invitrogen MA5-15867 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CrkL Monoclonal Antibody (5E12)

catalog :

MA5-15867

quantity :

100 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5.00E+12

reactivity :

human, mouse

application :

western blot, ELISA, flow cytometry

product information

Product Type :

Antibody

Product Name :

CrkL Monoclonal Antibody (5E12)

Catalog # :

MA5-15867

Quantity :

100 uL

Price :

US 480.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: 1:10,000, Flow Cytometry: 1:200-1:400, Western Blot: 1:500-1:2,000

Species :

Human, Mouse

Clone :

5.00E+12

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The CRKL gene encodes the CRK-like protein, an adaptor protein that plays a crucial role in intracellular signaling pathways related to cell proliferation, differentiation, and migration. CRKL contains SH2 and SH3 domains that facilitate interactions with other signaling molecules, influencing multiple pathways such as the MAPK, PI3K, and STAT pathways. It is involved in processes like cytoskeleton reorganization and immune cell signaling, with significant implications for development and cancer. CRKL is notably associated with Philadelphia chromosome-positive leukemias, where it interacts with the BCR-ABL fusion protein, contributing to leukemogenesis. Additionally, dysregulation of CRKL can affect cardiovascular development, leading to congenital heart defects. Research into CRKL focuses on understanding its role in signal transduction and its potential as a therapeutic target due to its involvement in oncogenic and developmental pathways.

Immunogen :

Purified recombinant fragment of human CRKL expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:10,000, Flow Cytometry: 1:200-1:400, Western Blot: 1:500-1:2,000

Aliases :

1110025F07Rik; AA589403; AI325100; CRK like proto-oncogene, adaptor protein; CRKL; crkl {ECO:0000312; crk-like protein; crk-like protein {ECO:0000250; Crkol; EMBL:AAH85865.1, ECO:0000312; OTTHUMP00000198539; RGD:1308531}; UniProtKB:P46109}; v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v-crk sarcoma virus CT10 oncogene homolog-like