SMN1 Monoclonal Antibody (5H1) | Invitrogen MA5-15858 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SMN1 Monoclonal Antibody (5H1)

catalog :

MA5-15858

quantity :

100 µL

price :

US 526

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5H1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...	Herrmann O, Schemionek M. Tumor Suppressor Analysis in CML. Methods Mol Biol. 2016;1465:87-94 pubmed publisher

image

image 1 :

Immunofluorescence analysis of HepG2 cells using MA5-15858 anti-SMN1 antibody (green). Blue staining is DRAQ5 fluorescent DNA dye and Red staining of Actin filaments was Alexa Fluor-555 phalloidin.

image 2 :

Immunohistochemical analysis of paraffin-embedded breast cancer tissues (left) and testis tissues (right) using MA5-15858 anti-SMN1 antibody with DAB staining.

product information

Product Type :

Antibody

Product Name :

SMN1 Monoclonal Antibody (5H1)

Catalog # :

MA5-15858

Quantity :

100 µL

Price :

US 526

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Immunocytochemistry: 1:200-1:1000, Immunofluorescence: 1/200 - 1/1000, Immunohistochemistry: 1/200 - 1/1000, Western Blot: 1/500 - 1/2000

Species :

Human, Non-human primate

Clone :

5H1

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein - survival motor neuron protein. The SMN complex plays a catalyst role in the assemble of small nuclear ribonucleoproteins, the building blocks of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy 1/2.

Immunogen :

Purified recombinant fragment of human SMN1 expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:200-1:1000, Immunofluorescence: 1/200 - 1/1000, Immunohistochemistry: 1/200 - 1/1000, Western Blot: 1/500 - 1/2000

Aliases :

AI849087; BCD541; Component of gems 1; GEMIN1; gemin-1; SMA; SMA@; SMA1; SMA2; SMA3; SMA4; SMN; SMN1; SMN2; SMNC; SMNT; survival motor neuron 1; survival motor neuron 1 protein; survival motor neuron protein; survival of motor neuron 1, telomeric; survival of motor neuron protein; T-BCD541; TDRD16A; tudor domain containing 16A

more info or order :

Invitrogen product webpage