FALZ Monoclonal Antibody (2F10) | Invitrogen MA5-15842 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FALZ Monoclonal Antibody (2F10)

catalog :

MA5-15842

quantity :

100 uL

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2F10

The same clone is also sold as:

OriGene: AM06615SU-N

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

FALZ Monoclonal Antibody (2F10)

Catalog # :

MA5-15842

Quantity :

100 uL

Price :

US 491.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 1:10,000, Immunocytochemistry: 1:200, Western Blot: 1:500-1:2,000

Species :

Human

Clone :

2F10

Isotype :

IgG2b

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).

Immunogen :

Purified recombinant fragment of human BPTF expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:10,000, Immunocytochemistry: 1:200, Western Blot: 1:500-1:2,000

Aliases :

9430093H17Rik; BPTF; bromodomain and PHD domain transcription factor; bromodomain and PHD finger-containing transcription factor; bromodomain PHD finger transcription factor; FAC1; FALZ; fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; fetal Alzheimer antigen; nucleosome remodeling factor, large subunit; nucleosome-remodeling factor subunit BPTF; NURF301