BMPR2 Monoclonal Antibody (3F6F8) | Invitrogen MA5-15827 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

BMPR2 Monoclonal Antibody (3F6F8)

catalog :

MA5-15827

quantity :

100 µg

price :

US 428

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3F6F8

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; bovine; 1:400; loading ...; fig 4b	Workman A, Zhu L, Keel B, Smith T, Jones C. The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency. J Virol. 2018;92: pubmed publisher
	Kabwe J, Sawada H, Mitani Y, Oshita H, Tsuboya N, Zhang E, et al. CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension. Respir Res. 2022;23:87 pubmed publisher
	Szulcek R, Sanchez Duffhues G, Rol N, Pan X, Tsonaka R, Dickhoff C, et al. Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells. Angiogenesis. 2020;23:699-714 pubmed publisher
	Happé C, Kurakula K, Sun X, da Silva Gonçalves Bós D, Rol N, Guignabert C, et al. The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient. Cells. 2020;9: pubmed publisher
	Qian S, Pan J, Su Y, Tang Y, Wang Y, Zou Y, et al. BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice. Commun Biol. 2020;3:200 pubmed publisher
	Gorrell R, Totten M, Schoerning L, Newby J, Geyman L, Lawless W, et al. Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody. BMC Res Notes. 2019;12:331 pubmed publisher
	Yuan H, Sehgal P. MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9). PLoS ONE. 2016;11:e0166382 pubmed publisher
	Perros F, GÃ¼nther S, Ranchoux B, Godinas L, Antigny F, Chaumais M, et al. Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models. Circulation. 2015;132:834-47 pubmed publisher
	Ranchoux B, Antigny F, Rucker Martin C, Hautefort A, PÃ©choux C, Bogaard H, et al. Endothelial-to-mesenchymal transition in pulmonary hypertension. Circulation. 2015;131:1006-18 pubmed publisher

image

image 1 :

Immunofluorescence analysis of Eca109 cells using MA5-15827 anti-BMPR2 antibody (green). Blue staining is DRAQ5 fluorescent DNA dye and Red staining of Actin filaments was Alexa Fluor-555 phalloidin.

image 2 :

Immunohistochemical analysis of paraffin-embedded muscle tissues (left) and kidney cancer tissues (right) using MA5-15827 anti-BMPR2 antibody with DAB staining.

product information

Product Type :

Antibody

Product Name :

BMPR2 Monoclonal Antibody (3F6F8)

Catalog # :

MA5-15827

Quantity :

100 µg

Price :

US 428

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Flow Cytometry: 1:100-1:200, Immunocytochemistry: 1:100-1:200, Immunohistochemistry (Paraffin): 2-4 ug/mL, Western Blot: 1:500-1:1,000

Species :

Human, Mouse, Non-human primate, Rat

Clone :

3F6F8

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

Immunogen :

Purified recombinant fragment of human BMPR2 expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:100-1:200, Immunocytochemistry: 1:100-1:200, Immunohistochemistry (Paraffin): 2-4 ug/mL, Western Blot: 1:500-1:1,000

Aliases :

2610024H22Rik; AL117858; AW546137; BB189135; BMP type II receptor; BMP type-2 receptor; BMP-2; BMPR2; BMPR-2; BMPR3; BMPRII; Bmpr-II; BMR2; bone morphogenetic protein receptor type 2; bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; Gm20272; POVD1; PPH1; T-ALK; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4

more info or order :

Invitrogen product webpage