HPV Type 16 E7 Monoclonal Antibody (6F3) | Invitrogen MA5-15822 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HPV Type 16 E7 Monoclonal Antibody (6F3)

catalog :

MA5-15822

quantity :

100 uL

price :

US 504.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6F3

The same clone is also sold as:

MyBioSource: MBS476143
OriGene: AM06592SU-N

reactivity :

Human papillomavirus type 16

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Bacigalupo I, Palladino C, Leone P, Toschi E, Sgadari C, Ensoli B, et al. Inhibition of MMP-9 expression by ritonavir or saquinavir is associated with inactivation of the AKT/Fra-1 pathway in cervical intraepithelial neoplasia cells. Oncol Lett. 2017;13:2903-2908 pubmed publisher

product information

Product Type :

Antibody

Product Name :

HPV Type 16 E7 Monoclonal Antibody (6F3)

Catalog # :

MA5-15822

Quantity :

100 uL

Price :

US 504.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Virus

Applications :

ELISA: 1:10,000, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 1:500-1:2,000

Species :

Virus

Clone :

6F3

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15kDa), zinc binding phosphoproteins which are localised in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A. Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumour suppressor protein pRb.

Immunogen :

Purified recombinant fragment of E7 expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:10,000, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 1:500-1:2,000

Aliases :

HPV 16-E7; HPV16E7; human papillomavirus