IRAK1 Monoclonal Antibody (8F1A7) | Invitrogen MA5-15783 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IRAK1 Monoclonal Antibody (8F1A7)

catalog :

MA5-15783

quantity :

100 ug

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8F1A7

The same clone is also sold as:

Rockland Immunochemicals: 200-301-BZ2

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

citations: 1

Reference
Icli B, Li H, Pérez Cremades D, Wu W, Ozdemir D, Haemmig S, et al. MiR-4674 regulates angiogenesis in tissue injury by targeting p38K signaling in endothelial cells. Am J Physiol Cell Physiol. 2020;318:C524-C535 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IRAK1 Monoclonal Antibody (8F1A7)

Catalog # :

MA5-15783

Quantity :

100 ug

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry: 5 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Mouse, Rat

Clone :

8F1A7

Isotype :

IgG1

Storage :

-20 C

Description :

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.

Immunogen :

Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 5 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841