PD-1 Monoclonal Antibody (7A11B1) | Invitrogen MA5-15780 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PD-1 Monoclonal Antibody (7A11B1)

catalog :

MA5-15780

quantity :

100 µg

price :

US 408.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7A11B1

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat; loading ...; fig 4f immunoprecipitation; rat; loading ...; fig 2b immunocytochemistry; rat; loading ...; fig 5b western blot; rat; loading ...; fig 3b	Wu J, Sun L, Li H, Shen H, Zhai W, Yu Z, et al. Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype. J Neuroinflammation. 2017;14:36 pubmed publisher
	Gelsomino L, Naimo G, Malivindi R, Augimeri G, Panza S, Giordano C, et al. Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression. Cancers (Basel). 2020;12: pubmed publisher
	Maj T, Wang W, Crespo J, Zhang H, Wang W, Wei S, et al. Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor. Nat Immunol. 2017;18:1332-1341 pubmed publisher

image

image 1 :

Western blot analysis of PD-1 in A-20 cell lysate with PD-1 antibody at 1 ug/mL in the (A) absence and (B) presence of blocking recombinant protein.

image 2 :

Immunohistochemistry staining of mouse brain tissue using MA5-15780 anti-PD-1 antibody at a concentration of 2.5 ug/mL.

product information

Product Type :

Antibody

Product Name :

PD-1 Monoclonal Antibody (7A11B1)

Catalog # :

MA5-15780

Quantity :

100 µg

Price :

US 408.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry: 2.5 µg/mL, Western Blot: 1 µg/mL

Species :

Human, Mouse, Rat

Clone :

7A11B1

Isotype :

IgG1

Storage :

-20°C

Description :

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Immunogen :

A ~150 amino acid recombinant protein from near the amino terminus of mouse PD-1

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 2.5 µg/mL, Western Blot: 1 µg/mL

Aliases :

CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2

more info or order :

Invitrogen product webpage