MD-2 Monoclonal Antibody (9F1B1) | Invitrogen MA5-15765 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MD-2 Monoclonal Antibody (9F1B1)

catalog :

MA5-15765

quantity :

100 µg

price :

US 413.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9F1B1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 2.5-10 ug/ml immunocytochemistry; human; 1:100	Lu Z, Li Y, Samuvel D, Jin J, Zhang X, Lopes Virella M, et al. MD-2 is involved in the stimulation of matrix metalloproteinase-1 expression by interferon-γ and high glucose in mononuclear cells - a potential role of MD-2 in Toll-like receptor 4-independent signalling. Immunology. 2013;140:301-13 pubmed publisher

image

image 1 :

Western blot analysis of (A) 25 and (B) 125 ng of MD-2 recombinant protein with MD-2 antibody at 1 ug/mL.

product information

Product Type :

Antibody

Product Name :

MD-2 Monoclonal Antibody (9F1B1)

Catalog # :

MA5-15765

Quantity :

100 µg

Price :

US 413.00

Clonality :

Monoclonal

Purity :

Antigen affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry: 2.5 µg/mL, Western Blot: 1 µg/mL

Species :

Human, Mouse

Clone :

9F1B1

Isotype :

IgG1

Storage :

-20°C

Description :

Toll-like receptors (TLRs) are evolutionarily conserved patternrecognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD -1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.

Immunogen :

Recombinant protein corresponding to amino acids 2 to 160 of human MD-2

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 2.5 µg/mL, Western Blot: 1 µg/mL

Aliases :

Esop1; ESOP-1; LPS co-receptor MD-2; LY96; ly-96; Lymphocyte antigen 96; MD2; MD-2; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2

more info or order :

Invitrogen product webpage