PUMA alpha Monoclonal Antibody (10D4G7) | Invitrogen MA5-15755 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PUMA alpha Monoclonal Antibody (10D4G7)

catalog :

MA5-15755

quantity :

100 ug

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10D4G7

The same clone is also sold as:

OriGene: TA319892
Rockland Immunochemicals: 200-301-DV2

reactivity :

human, rat

application :

western blot

product information

Product Type :

Antibody

Product Name :

PUMA alpha Monoclonal Antibody (10D4G7)

Catalog # :

MA5-15755

Quantity :

100 ug

Price :

US 474.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Rat

Applications :

Western Blot: 2.5-5 ug/mL

Species :

Human, Rat

Clone :

10D4G7

Isotype :

IgG1

Storage :

-20 C

Description :

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Immunogen :

Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 2.5-5 ug/mL

Aliases :

BBC3; BCL2 binding component 3; Bcl-2 binding component 3; bcl-2-binding component 3; Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; BH3-only; FLJ42994; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1