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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
GAPDH Loading Control Monoclonal Antibody (GA1R), HRP
catalog :
MA5-15738-HRP
quantity :
50 uL
price :
US 276.00
clonality :
monoclonal
host :
mouse
conjugate :
HRP
clone name :
GA1R
reactivity :
Chinese hamsters, human, mouse, rat, chicken, domestic rabbit
application :
western blot
more info or order :
citations: 48
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:3000; loading ...; fig 2a
Tullett K, Tan P, Park H, Schittenhelm R, Michael N, Li R, et al. RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells. elife. 2020;9: pubmed publisher
  • western blot; human
Liu Y, Chen C, Xu Z, Scuoppo C, Rillahan C, Gao J, et al. Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature. 2016;531:471-475 pubmed publisher
Jun L, Ding X, Robinson M, Jafari H, Knight E, Geetha T, et al. Targeting Molecular Mechanisms of Obesity- and Type 2 Diabetes Mellitus-Induced Skeletal Muscle Atrophy with Nerve Growth Factor. Int J Mol Sci. 2024;25: pubmed publisher
Sung H, Tang J, Jahng J, Song E, Chan Y, Lone A, et al. Ischemia-induced cardiac dysfunction is exacerbated in adiponectin-knockout mice due to impaired autophagy flux. Clin Transl Sci. 2024;17:e13758 pubmed publisher
Fuentes Y, Olgu xed n V, L xf3 pez Ulloa B, Mendon xe7 a D, Ramos H, Abdalla A, et al. Heterogeneous nuclear ribonucleoprotein K promotes cap-independent translation initiation of retroviral mRNAs. Nucleic Acids Res. 2024;52:2625-2647 pubmed publisher
Terron H, Maranan D, Burgard L, LaFerla F, Lane S, Leissring M. A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D. Int J Mol Sci. 2023;24: pubmed publisher
Imre G, Tak xe1 cs B, Czipa E, Drubi A, Jaksa G, Latinovics D, et al. Prolonged activity of the transposase helper may raise safety concerns during DNA transposon-based gene therapy. Mol Ther Methods Clin Dev. 2023;29:145-159 pubmed publisher
Goldberg A, Ferguson M, Pal S, Cohen R, Orlicky D, McCullough R, et al. Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin. Front Physiol. 2022;13:1021038 pubmed publisher
Berroyer A, Bacolla A, Tainer J, Kim N. Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability. Microb Cell. 2022;9:52-68 pubmed publisher
Kunath N, Bugaj A, Bigonah P, Fernandez Berrocal M, Bj xf8 r xe5 s M, Ye J. DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons. iScience. 2021;24:103470 pubmed publisher
Cuitavi J, Lorente J, Campos Jurado Y, Polache A, Hip xf3 lito L. Neuroimmune and Mu-Opioid Receptor Alterations in the Mesocorticolimbic System in a Sex-Dependent Inflammatory Pain-Induced Alcohol Relapse-Like Rat Model. Front Immunol. 2021;12:689453 pubmed publisher
Tidu F, De Zuani M, Jose S, Bendickova K, Kubala L, Caruso F, et al. NFAT signaling in human mesenchymal stromal cells affects extracellular matrix remodeling and antifungal immune responses. iScience. 2021;24:102683 pubmed publisher
Popay T, Wang J, Adams C, Howard G, Codreanu S, Sherrod S, et al. MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1. elife. 2021;10: pubmed publisher
Lucas E, Schafer J, Matsuda J, Kraus M, Burchill M, Tamburini B. PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity. Cell Rep. 2020;33:108258 pubmed publisher
Burchill M, Finlon J, Goldberg A, Gillen A, Dahms P, McMahan R, et al. Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System. Cell Mol Gastroenterol Hepatol. 2021;11:573-595 pubmed publisher
Krzeminska P, Stachowiak M, Skrzypski M, Nowak T, Maslak A, Switonski M. Altered expression of CYP17A1 and CYP19A1 in undescended testes of dogs with unilateral cryptorchidism. Anim Genet. 2020;51:763-771 pubmed publisher
Gray S, Santiago E, Chappie J, Cohen P. Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. Cell Rep. 2020;32:107858 pubmed publisher
Polenghi A, Nieus T, Guazzi S, Gorostiza P, Petrini E, Barberis A. Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses. Cell Rep. 2020;31:107735 pubmed publisher
Koch C, Buono S, Menuet A, Robe A, Djeddi S, Kretz C, et al. Myostatin: a Circulating Biomarker Correlating with Disease in Myotubular Myopathy Mice and Patients. Mol Ther Methods Clin Dev. 2020;17:1178-1189 pubmed publisher
Yung L, Yang P, Joshi S, Augur Z, Kim S, Bocobo G, et al. ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension. Sci Transl Med. 2020;12: pubmed publisher
Zhang Z, Yang N. MiR-33a-5p inhibits the growth and metastasis of melanoma cells by targeting SNAI2. Neoplasma. 2020;67:813-824 pubmed publisher
Dinh P, Paudel D, Brochu H, Popowski K, Gracieux M, Cores J, et al. Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. Nat Commun. 2020;11:1064 pubmed publisher
Peleli M, Ferreira D, Tarnawski L, McCann Haworth S, Xuechen L, Zhuge Z, et al. Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status. Redox Biol. 2020;28:101387 pubmed publisher
Dey S, Kwon J, Liu S, Hodge G, Taleb S, Zimmers T, et al. miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2. Mol Cancer Res. 2020;18:311-323 pubmed publisher
Brüning F, Noya S, Bange T, Koutsouli S, Rudolph J, Tyagarajan S, et al. Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. Science. 2019;366: pubmed publisher
Dimas R, Jordan B, Jiang X, Martini C, Glavy J, Patterson D, et al. Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy. Nucleic Acids Res. 2019;47:8913-8925 pubmed publisher
Li D, Cho Y. High specificity of widely used phospho-tau antibodies validated using a quantitative whole-cell based assay. J Neurochem. 2020;152:122-135 pubmed publisher
Meydan S, Marks J, Klepacki D, Sharma V, Baranov P, Firth A, et al. Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome. Mol Cell. 2019;74:481-493.e6 pubmed publisher
Zhang J, Termglinchan V, Shao N, Itzhaki I, Liu C, Ma N, et al. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles. Cell Stem Cell. 2019;24:802-811.e5 pubmed publisher
Aho E, Wang J, Gogliotti R, Howard G, Phan J, Acharya P, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019;26:2916-2928.e13 pubmed publisher
Demirgan S, Akyol O, Temel Z, Şengelen A, Pekmez M, Demirgan R, et al. Isoflurane exposure in infant rats acutely increases aquaporin 4 and does not cause neurocognitive impairment. Bosn J Basic Med Sci. 2019;: pubmed publisher
Rodrigo R, Mendis N, Ibrahim M, Ma C, Kreinin E, Roma A, et al. Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugs. Autophagy. 2019;15:900-907 pubmed publisher
Cops J, Mullens W, Verbrugge F, Swennen Q, De Moor B, Reynders C, et al. Selective abdominal venous congestion induces adverse renal and hepatic morphological and functional alterations despite a preserved cardiac function. Sci Rep. 2018;8:17757 pubmed publisher
Ibrahim S, Xie W, Strong J, Tonello R, Berta T, Zhang J. Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci. 2018;12:453 pubmed publisher
Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham C, et al. Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation. Cell Rep. 2018;25:1816-1828.e4 pubmed publisher
Villiger L, Grisch Chan H, Lindsay H, Ringnalda F, Pogliano C, Allegri G, et al. Treatment of a metabolic liver disease by in vivo genome base editing in adult mice. Nat Med. 2018;24:1519-1525 pubmed publisher
Bradley T, Peppa D, Pedroza Pacheco I, Li D, Cain D, Henao R, et al. RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Cell. 2018;175:387-399.e17 pubmed publisher
Nguyen T, Duchon A, Manousopoulou A, Loaëc N, Villiers B, Pani G, et al. Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A. Dis Model Mech. 2018;11: pubmed publisher
Yu J, Li Y, Wang T, Zhong X. Modification of N6-methyladenosine RNA methylation on heat shock protein expression. PLoS ONE. 2018;13:e0198604 pubmed publisher
Halperin Kuhns V, Pluznick J. Novel differences in renal gene expression in a diet-induced obesity model. Am J Physiol Renal Physiol. 2018;314:F517-F530 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
GAPDH Loading Control Monoclonal Antibody (GA1R), HRP
Catalog # :
MA5-15738-HRP
Quantity :
50 uL
Price :
US 276.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Bacteria, Chicken, Hamster, Human, Insect, Mouse, Rabbit, Rat, Yeast
Applications :
Western Blot: 1:500-1:2,000
Species :
Bacteria, Chicken, Hamster, Human, Insect, Mouse, Rabbit, Rat, Yeast
Clone :
GA1R
Isotype :
IgG1
Storage :
4 C
Description :
GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington's disease. Associations between GAPDH, actin and tubulin have also be reported. Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.
Immunogen :
Recombinant GAPDH
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1:500-1:2,000
Aliases :
38 kDa BFA-dependent ADP-ribosylation substrate; aging-associated gene 9 protein; BARS-38; bb02e05; cb350; cb609; CDABP0047; EC 1.2.1.12; epididymis secretory protein Li 278; epididymis secretory sperm binding protein Li 162eP; fb71f08; fk58c09; G3PD; G3PDH; GAPD; GAPD2; gapdh; GAPDH2; GAPDH-2; GAPDHS; Gapds; Gapd-s; glceraldehyde-3-phosphate dehydrogenase; glyceraldehyde 3-phosphate dehydrogenase; glyceraldehyde 3-phosphate dehydrogenase, testis-specific; glyceraldehyde phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase (G3PDH); glyceraldehyde-3-phosphate dehydrogenase 2; glyceraldehyde-3-phosphate dehydrogenase GAPDH; glyceraldehyde-3-phosphate dehydrogenase like-17 protein; glyceraldehyde-3-phosphate dehydrogenase type 2; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; glyceraldehyde-3-phosphate dehydrogenase, testis-specific; glyceraldehyde-phosphate-dehydrogenase; glycerine aldehyde 3-phosphate dehydrogenase; HEL-S-162eP; HEL-S-278; HGNC:4141; HSD35; HSD-35; I79_001391; KNC-NDS6; LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase, testis-specific; mg:bb02e05; MGC128279 protein; MGC88685; multifunctional protein, glycolytic enzyme; OK/SW-cl.12; Peptidyl-cysteine S-nitrosylase GAPDH; similar to glyceraldehyde 3-phosphate dehydrogenase; spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; Spermatogenic glyceraldehyde-3-phosphate dehydrogenase; Unknown (protein for IMAGE:8101613); unnamed protein product; wu:fb33a10; wu:fb71f08; wu:fk58c09; wu:ft80f05; zgc:76908
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA