VEGF Receptor 2 Monoclonal Antibody (4B4) | Invitrogen MA5-15556 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

VEGF Receptor 2 Monoclonal Antibody (4B4)

catalog :

MA5-15556

quantity :

100 µL

price :

US 476

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B4

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:600; fig 5	El Alaoui Lasmaili K, Djermoune E, Tylcz J, Meng D, PlÃ©nat F, Thomas N, et al. A new algorithm for a better characterization and timing of the anti-VEGF vascular effect named "normalization". Angiogenesis. 2017;20:149-162 pubmed publisher
	Sphyris N, King C, Hoar J, Werden S, Vijay G, Miura N, et al. Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth. Oncotarget. 2021;12:823-844 pubmed publisher
	Galego S, Kauppila L, Malhó R, Pimentel J, Brito M. Myocyte Enhancer Factor 2C as a New Player in Human Breast Cancer Brain Metastases. Cells. 2021;10: pubmed publisher

image

image 1 :

Confocal immunofluorescence analysis of Hela (left) and HepG2 (right) cells using KDR antibody (green). Blue: DRAQ5 fluorescent DNA dye.

product information

Product Type :

Antibody

Product Name :

VEGF Receptor 2 Monoclonal Antibody (4B4)

Catalog # :

MA5-15556

Quantity :

100 µL

Pricing :

US 476

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 1:10,000, Flow Cytometry: 1/200 - 1/400, Immunocytochemistry: 1:200-1:1,000, Western Blot: 1:500-1:2,000

Species :

Human

Clone :

4B4

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas.

Immunogen :

Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:10,000, Flow Cytometry: 1/200 - 1/400, Immunocytochemistry: 1:200-1:1,000, Western Blot: 1:500-1:2,000

Aliases :

6130401C07; CD309; CD309 antigen; fetal liver kinase 1; fetal liver kinase-1; FLK1; Flk-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); flk-1 type VEGF receptor; KDR; kinase insert domain protein receptor; kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); kinase NYK; Krd-1; Ly73; protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; sVEGFR-2; tyrosine kinase growth factor receptor; vascular endotheial growth factor 2; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR; VEGFR2; VEGFR-2

more info or order :

Invitrogen product webpage