HPV Type 16 E7 Monoclonal Antibody (3D6F1) | Invitrogen MA5-15439 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HPV Type 16 E7 Monoclonal Antibody (3D6F1)

catalog :

MA5-15439

quantity :

100 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D6F1

application :

western blot, ELISA

citations: 2

Reference
Barillari G, Palladino C, Bacigalupo I, Leone P, Falchi M, Ensoli B. Entrance of the Tat protein of HIV-1 into human uterine cervical carcinoma cells causes upregulation of HPV-E6 expression and a decrease in p53 protein levels. Oncol Lett. 2016;12:2389-2394 pubmed
Qin Y, Wang X, Cui H, Cheung Y, Hu M, Zhu S, et al. Human papillomavirus type 16 E7 peptide(38-61) linked with an immunoglobulin G fragment provides protective immunity in mice. Gynecol Oncol. 2005;96:475-83 pubmed

product information

Product Type :

Antibody

Product Name :

HPV Type 16 E7 Monoclonal Antibody (3D6F1)

Catalog # :

MA5-15439

Quantity :

100 uL

Price :

US 480.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Virus

Applications :

ELISA: 1:10,000, Western Blot: 1:500-1:2,000

Species :

Virus

Clone :

3D6F1

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15kDa), zinc binding phosphoproteins which are localised in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A. Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumour suppressor protein pRb.

Immunogen :

Purified recombinant full-lenght E7 expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:10,000, Western Blot: 1:500-1:2,000

Aliases :

HPV 16-E7; HPV16E7; human papillomavirus