Phospho-beta Arrestin 1 (Ser412) Monoclonal Antibody (H.992.9) | Invitrogen MA5-15217 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-beta Arrestin 1 (Ser412) Monoclonal Antibody (H.992.9)

catalog :

MA5-15217

quantity :

100 uL

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

H.992.9

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

product information

Product Type :

Antibody

Product Name :

Phospho-beta Arrestin 1 (Ser412) Monoclonal Antibody (H.992.9)

Catalog # :

MA5-15217

Quantity :

100 uL

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Immunoprecipitation: 1:50, Western Blot: 1:1,000

Species :

Human, Mouse, Non-human primate, Rat

Clone :

H.992.9

Isotype :

IgG1

Storage :

-20 C

Description :

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

Immunogen :

Synthetic peptide corresponding to residues surrounding Ser412 of human ß-arrestin 1

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: 1:50, Western Blot: 1:1,000

Aliases :

1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2