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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-c-Raf (Ser338) Monoclonal Antibody (E.838.4)
catalog :
MA5-15176
quantity :
100 µL
price :
US 375.00
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
E.838.4
reactivity :
human, mouse, rat
application :
western blot
more info or order :
Invitrogen product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:5000; loading ...; fig 4c
Mitra S, Ghosh B, Gayen N, Roy J, Mandal A. Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation. J Biol Chem. 2016;291:24579-24593 pubmed
Ibrahim W, Abdelkader N, Ismail H, Khattab M. Escitalopram Ameliorates Cognitive Impairment in D-Galactose-Injected Ovariectomized Rats: Modulation of JNK, GSK-3β, and ERK Signalling Pathways. Sci Rep. 2019;9:10056 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Phospho-c-Raf (Ser338) Monoclonal Antibody (E.838.4)
Catalog # :
MA5-15176
Quantity :
100 µL
Price :
US 375.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Non-human primate, Rat
Applications :
Western Blot: 1:1,000
Species :
Human, Mouse, Non-human primate, Rat
Clone :
E.838.4
Isotype :
IgG
Storage :
-20°C
Description :
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Immunogen :
Synthetic phosphopeptide corresponding to residues surrounding serine 338 of human Raf
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1:1,000
Aliases :
6430402F14Rik; AA990557; BB129353; CMD1NN; CRAF; C-RAF; C-Raf proto-oncogene, serine/threonine kinase; Craf1; Craf1 transforming; D830050J10Rik; EC 2.7.11.1; kinase Raf1; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); murine sarcoma 3611 oncogene 1; NS5; Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; proto-oncogene c-RAF; RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; RAF1; Raf-1; Raf-1 proto-oncogene, serine/threonine kinase; sarcoma 3611 oncogene; v-Raf; v-raf-1 leukemia viral oncogene 1; vraf1 murine le; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; v-raf-leukemia viral oncogene 1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA