Bcl-xL Monoclonal Antibody (C.85.1) | Invitrogen MA5-15142 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bcl-xL Monoclonal Antibody (C.85.1)

catalog :

MA5-15142

quantity :

100 µL

price :

US 425.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

C.85.1

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:2000; loading ...; fig 8	Singh M, Kasna S, Roy S, Aldosary S, Saeedan A, Ansari M, et al. Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signalling. BMC Cancer. 2019;19:996 pubmed publisher
	Su W, Wang L, Fu X, Ni L, Duan D, Xu J, et al. Protective Effect of a Fucose-Rich Fucoidan Isolated from Saccharina japonica against Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish. Mar Drugs. 2020;18: pubmed publisher
	Roy S, Rawat A, Sammi S, Devi U, Singh M, Gautam S, et al. Alpha-linolenic acid stabilizes HIF-1 ? and downregulates FASN to promote mitochondrial apoptosis for mammary gland chemoprevention. Oncotarget. 2017;8:70049-70071 pubmed publisher

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product information

Product Type :

Antibody

Product Name :

Bcl-xL Monoclonal Antibody (C.85.1)

Catalog # :

MA5-15142

Quantity :

100 µL

Price :

US 425.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Flow Cytometry: 1:800, Immunocytochemistry: 1:200, Immunohistochemistry (Frozen): 1:1200, Immunohistochemistry (Paraffin): 1:1200, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Species :

Human, Mouse, Non-human primate, Rat

Clone :

C.85.1

Isotype :

IgG

Storage :

-20°C

Description :

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Immunogen :

Synthetic peptide corresponding to residues surrounding Asp61 of human Bcl-xL

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:800, Immunocytochemistry: 1:200, Immunohistochemistry (Frozen): 1:1200, Immunohistochemistry (Paraffin): 1:1200, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Aliases :

anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl(X)L; BCL2 like 1; Bcl2l; BCL2L1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCLX; bcl-x; BCLXL; Bcl-XL; BCL-XL/S; BCLXS; bcl-xS; Blc2l; DKFZp781P2092; EGK_02534; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3

more info or order :

Invitrogen product webpage