TSC1 Monoclonal Antibody (K.624.6) | Invitrogen MA5-15104 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TSC1 Monoclonal Antibody (K.624.6)

catalog :

MA5-15104

quantity :

100µL

price :

325.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

K.624.6

reactivity :

human, mouse, rat

application :

western blot

product information

Product Type :

Antibody

Product Name :

TSC1 Monoclonal Antibody (K.624.6)

Catalog # :

MA5-15104

Quantity :

100µL

Price (USD) :

325.00 USD

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:1000

Species :

Human, Mouse, Rat

Clone :

K.624.6

Isotype :

IgG1

Storage :

-20°C

Description :

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.

Immunogen :

Recombinant protein from the central region of human harmartin

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1000

Aliases :

hamartin; HGNC:12362; KIAA0243; LAM; MGC86987; OTTHUMP00000022439; OTTHUMP00000198378; TSC; TSC1; tuberous sclerosis 1; Tuberous sclerosis 1 protein; Tuberous sclerosis 1 protein homolog; tumor suppressor