Phospho-STAT1 (Tyr701) Monoclonal Antibody (S.213.5) | Invitrogen MA5-15071 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-STAT1 (Tyr701) Monoclonal Antibody (S.213.5)

catalog :

MA5-15071

quantity :

100 uL

price :

US 464.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

S.213.5

reactivity :

African green monkey, human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:500; fig 4b western blot; African green monkey; 1:500; fig 4a	Kint J, Dickhout A, Kutter J, Maier H, Britton P, Koumans J, et al. Infectious Bronchitis Coronavirus Inhibits STAT1 Signaling and Requires Accessory Proteins for Resistance to Type I Interferon Activity. J Virol. 2015;89:12047-57 pubmed publisher
	Lamers M, van der Vaart J, Knoops K, Riesebosch S, Breugem T, Mykytyn A, et al. An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells. EMBO J. 2021;40:e105912 pubmed publisher
	Gandalovičová A, Šůchová A, Cermák V, Merta L, Rosel D, Brabek J. Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells. Cancers (Basel). 2020;12: pubmed publisher
	Cao M, Zhu B, Sun Y, Qiu G, Fu W, Jiang H. MicroRNA-144 Regulates Cardiomyocyte Proliferation and Apoptosis by Targeting TBX1 through the JAK2/STAT1 Pathway. Cytogenet Genome Res. 2019;159:190-200 pubmed publisher
	Ramia E, Chiaravalli A, Bou Nasser Eddine F, Tedeschi A, Sessa F, Accolla R, et al. CIITA-related block of HLA class II expression, upregulation of HLA class I, and heterogeneous expression of immune checkpoints in hepatocarcinomas: implications for new therapeutic approaches. Oncoimmunology. 2019;8:1548243 pubmed publisher
	Ibana J, Sherchand S, Fontanilla F, Nagamatsu T, Schust D, Quayle A, et al. Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma. Sci Rep. 2018;8:8476 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-STAT1 (Tyr701) Monoclonal Antibody (S.213.5)

Catalog # :

MA5-15071

Quantity :

100 uL

Price :

US 464.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ChIP Assay: 1:100, Flow Cytometry: 1:100-1:400, Immunocytochemistry: 1:200-1:800, Immunohistochemistry (Paraffin): 1:400-1:1,600, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Species :

Human, Mouse

Clone :

S.213.5

Isotype :

IgG

Storage :

-20 C

Description :

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

Immunogen :

Synthetic phosphopeptide corresponding to residues surrounding pTyr701 of human Stat1

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1:100, Flow Cytometry: 1:100-1:400, Immunocytochemistry: 1:200-1:800, Immunohistochemistry (Paraffin): 1:400-1:1,600, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Aliases :

2010005J02Rik; AA408197; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT1; STAT-1; stat1 alpha; STAT91; transcription factor ISGF-3; transcription factor ISGF-3 components p91/p84

more info or order :

Invitrogen product webpage