IRS1 Monoclonal Antibody (K.346.8) | Invitrogen MA5-15068 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IRS1 Monoclonal Antibody (K.346.8)

catalog :

MA5-15068

quantity :

100µL

price :

US 305

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

K.346.8

reactivity :

human, mouse, rat, pigs

application :

western blot

more info or order :

Invitrogen product webpage

citations: 4

Reference
Vidotto A, Polachini G, de Paula Silva M, Oliani S, Henrique T, López R, et al. Differentially expressed proteins in positive versus negative HNSCC lymph nodes. BMC Med Genomics. 2018;11:73 pubmed publisher
Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina Y, et al. Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. J Clin Invest. 2018;128:3341-3355 pubmed publisher
Zuo Y, Ulu A, Chang J, Frost J. Contributions of the RhoA guanine nucleotide exchange factor Net1 to polyoma middle T antigen-mediated mammary gland tumorigenesis and metastasis. Breast Cancer Res. 2018;20:41 pubmed publisher
Avivar Valderas A, McEwen R, Taheri Ghahfarokhi A, Carnevalli L, Hardaker E, Maresca M, et al. Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer. Oncotarget. 2018;9:21444-21458 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IRS1 Monoclonal Antibody (K.346.8)

Catalog # :

MA5-15068

Quantity :

100µL

Price :

US 305

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Porcine, Rat

Applications :

Western Blot: 1:1000

Species :

Human, Mouse, Porcine, Rat

Clone :

K.346.8

Isotype :

IgG

Storage :

-20°C

Description :

IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.

Immunogen :

Synthetic peptide corresponding to the sequence surrounding Ser307 of human IRS-1

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1000

Aliases :

G972R; HIRS-1; Insulin receptor substrate 1; IRS1; Irs-1; IRS1IRM; pp185

more info or order :

Invitrogen product webpage