TGF beta-1 Monoclonal Antibody (F.888.7) | Invitrogen MA5-15065 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TGF beta-1 Monoclonal Antibody (F.888.7)

catalog :

MA5-15065

quantity :

100 µL

price :

US 470

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

F.888.7

reactivity :

human

application :

western blot

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
western blot; human	McLane J, Rivet C, Gilbert R, Ligon L. A biomaterial model of tumor stromal microenvironment promotes mesenchymal morphology but not epithelial to mesenchymal transition in epithelial cells. Acta Biomater. 2014;10:4811-4821 pubmed publisher
	Wu M, Ge Y, Wang E, Liao Q, Ren Z, Yu Y, et al. Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation. EMBO Mol Med. 2023;15:e17815 pubmed publisher
	Nasser S, Abdallah D, Ahmed K, Abdel Mottaleb Y, El Abhar H. The novel anti-colitic effect of β-adrenergic receptors via modulation of PS1/BACE-1/Aβ axis and NOTCH signaling in an ulcerative colitis model. Front Pharmacol. 2022;13:1008085 pubmed publisher
	Górowska Wójtowicz E, Duliban M, Kotula Balak M, Bilinska B. Modulatory Effects of Estradiol and Its Mixtures with Ligands of GPER and PPAR on MAPK and PI3K/Akt Signaling Pathways and Tumorigenic Factors in Mouse Testis Explants and Mouse Tumor Leydig Cells. Biomedicines. 2022;10: pubmed publisher
	Brunetti R, Kockelkoren G, Raghavan P, Bell G, Britain D, Puri N, et al. WASP integrates substrate topology and cell polarity to guide neutrophil migration. J Cell Biol. 2022;221: pubmed publisher
	Huang S, Huang P, Wu H, Wang S, Liu G. LINC02381 aggravates breast cancer through the miR-1271-5p/FN1 axis to activate PI3K/AKT pathway. Mol Carcinog. 2022;61:346-358 pubmed publisher
	Saeed K, Jo M, Park J, Alam S, Khan I, Ahmad R, et al. 17β-Estradiol Abrogates Oxidative Stress and Neuroinflammation after Cortical Stab Wound Injury. Antioxidants (Basel). 2021;10: pubmed publisher
	Shrestha R, Bridle K, Cao L, Crawford D, Jayachandran A. Dual Targeting of Sorafenib-Resistant HCC-Derived Cancer Stem Cells. Curr Oncol. 2021;28:2150-2172 pubmed publisher
	Shrestha R, Prithviraj P, Bridle K, Crawford D, Jayachandran A. Combined Inhibition of TGF-β1-Induced EMT and PD-L1 Silencing Re-Sensitizes Hepatocellular Carcinoma to Sorafenib Treatment. J Clin Med. 2021;10: pubmed publisher
	Hritzo B, Aghdam S, Legesse B, Kaur A, Cao M, Boerma M, et al. Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling. Int J Mol Sci. 2021;22: pubmed publisher
	Chang L, Wang Q, Ju J, Li Y, Cai Q, Hao L, et al. Magnoflorine Ameliorates Inflammation and Fibrosis in Rats With Diabetic Nephropathy by Mediating the Stability of Lysine-Specific Demethylase 3A. Front Physiol. 2020;11:580406 pubmed publisher
	Li H, Kan B, Song L, Liu Y, Jian X. Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis. J Int Med Res. 2020;48:300060520905425 pubmed publisher
	McLane J, Ligon L. Palladin mediates stiffness-induced fibroblast activation in the tumor microenvironment. Biophys J. 2015;109:249-64 pubmed publisher

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product information

Product Type :

Antibody

Product Name :

TGF beta-1 Monoclonal Antibody (F.888.7)

Catalog # :

MA5-15065

Quantity :

100 µL

Price :

US 470

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 1:1,000

Species :

Human

Clone :

F.888.7

Isotype :

IgG

Storage :

-20°C

Description :

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.

Immunogen :

Synthetic peptide corresponding to a region in the carboxy terminus of TGF-ß1 protein

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF ß; TGF ß 1; TGF ß1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFß1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor ß1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product

more info or order :

Invitrogen product webpage