ATGL Monoclonal Antibody (K.751.7) | Invitrogen MA5-14990 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ATGL Monoclonal Antibody (K.751.7)

catalog :

MA5-14990

quantity :

100 µL

price :

US 472

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

K.751.7

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human	Grahn T, Kaur R, Yin J, Schweiger M, Sharma V, Lee M, et al. Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes. J Biol Chem. 2014;289:12029-39 pubmed publisher
	An M, Park Y, Lim Y. Antiobesity and antidiabetic effects of the dairy bacterium Propionibacterium freudenreichii MJ2 in high-fat diet-induced obese mice by modulating lipid metabolism. Sci Rep. 2021;11:2481 pubmed publisher
	Li L, Zhang X, Zhang Q, Jia J, Zhang J, Zhang D, et al. Myocardial Adipose Triglyceride Lipase Overexpression Protects against Burn-Induced Cardiac Lipid Accumulation and Injury. Oxid Med Cell Longev. 2019;2019:6428924 pubmed publisher
	Chen W, Jiang Y, Han J, Hu J, He T, Yan T, et al. Atgl deficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage. FEBS J. 2017;284:1070-1081 pubmed publisher

image

image 1 :

image 2 :

image 3 :

product information

Product Type :

Antibody

Product Name :

ATGL Monoclonal Antibody (K.751.7)

Catalog # :

MA5-14990

Quantity :

100 µL

Pricing :

US 472

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Mouse, Rat

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Species :

Mouse, Rat

Clone :

K.751.7

Isotype :

IgG

Storage :

-20°C

Description :

Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.

Immunogen :

Synthetic peptide corresponding to residues surrounding Pro469 of mouse ATGL

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Aliases :

0610039C21Rik; 1110001C14Rik; adipose triglyceride lipase; ATGL; ATGL DESNUTRIN; calcium-independent phospholipase A2; Desnutrin; DKFZp667M109; FP17548; IPLA2 zeta; iPLA2zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; plpl; plpl2; Pnpla2; RGD1309044; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2; TTS-2.2

more info or order :

Invitrogen product webpage