Phospho-IRF3 (Ser396) Monoclonal Antibody (E.875.8) | Invitrogen MA5-14947 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-IRF3 (Ser396) Monoclonal Antibody (E.875.8)

catalog :

MA5-14947

quantity :

100 uL

price :

US 464.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

E.875.8

reactivity :

human, mouse

application :

western blot

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig s1	Shi Y, Yuan B, Qi N, Zhu W, Su J, Li X, et al. An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response. Nat Commun. 2015;6:7811 pubmed publisher
	Eren R, Kaya G, Schwarzer R, Pasparakis M. IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nat Commun. 2024;15:130 pubmed publisher
	Jiang S, Xia N, Luo J, Zhang Y, Cao Q, Zhang J, et al. The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy. J Virol. 2022;96:e0147622 pubmed publisher
	Xia N, Zheng W, Jiang S, Cao Q, Luo J, Zhang J, et al. Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis. Front Immunol. 2022;13:1021384 pubmed publisher
	Ren Z, Ding T, He H, Wei Z, Shi R, Deng J. Mechanism of selenomethionine inhibiting of PDCoV replication in LLC-PK1 cells based on STAT3/miR-125b-5p-1/HK2 signaling. Front Immunol. 2022;13:952852 pubmed publisher
	Zheng W, Xia N, Zhang J, Cao Q, Jiang S, Luo J, et al. African Swine Fever Virus Structural Protein p17 Inhibits cGAS-STING Signaling Pathway Through Interacting With STING. Front Immunol. 2022;13:941579 pubmed publisher
	Ren Z, Jia G, He H, Ding T, Yu Y, Zuo Z, et al. Antiviral Effect of Selenomethionine on Porcine Deltacoronavirus in Pig Kidney Epithelial Cells. Front Microbiol. 2022;13:846747 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-IRF3 (Ser396) Monoclonal Antibody (E.875.8)

Catalog # :

MA5-14947

Quantity :

100 uL

Price :

US 464.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Western Blot: 1:1,000

Species :

Human, Mouse

Clone :

E.875.8

Isotype :

IgG

Storage :

-20 C

Description :

IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.

Immunogen :

Synthetic phosphopeptide corresponding to residues surrounding pSer396 of human IRF-3

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

C920001K05Rik; IIAE7; Interferon regulatory factor 3; IRF3; IRF-3; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3

more info or order :

Invitrogen product webpage