Thioredoxin 1 Monoclonal Antibody (H.753.8) | Invitrogen MA5-14941 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Thioredoxin 1 Monoclonal Antibody (H.753.8)

catalog :

MA5-14941

quantity :

100 uL

price :

US 474.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

H.753.8

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:2000; loading ...; fig 2d	Plugis N, Palanski B, Weng C, Albertelli M, Khosla C. Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine: IMPLICATIONS FOR CELIAC DISEASE. J Biol Chem. 2017;292:2000-2008 pubmed publisher
	Tudor M, Gilbert A, Lepleux C, Temelie M, Hem S, Armengaud J, et al. A Proteomic Study Suggests Stress Granules as New Potential Actors in Radiation-Induced Bystander Effects. Int J Mol Sci. 2021;22: pubmed publisher
	Pasha A, Vignoli M, Subbiani A, Nocentini A, Selleri S, Gratteri P, et al. β3-Adrenoreceptor Activity Limits Apigenin Efficacy in Ewing Sarcoma Cells: A Dual Approach to Prevent Cell Survival. Int J Mol Sci. 2019;20: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Thioredoxin 1 Monoclonal Antibody (H.753.8)

Catalog # :

MA5-14941

Quantity :

100 uL

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:400, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Clone :

H.753.8

Isotype :

IgG

Storage :

-20 C

Description :

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

Immunogen :

Synthetic peptide corresponding to residues surrounding Ala9 of human thioredoxin 1

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:400, Western Blot: 1:1,000

Aliases :

ADF; ATL-derived factor; AW550880; DKFZp686B1993; MGC61975; RP11-427L11.1; SASP; surface-associated sulphydryl protein; testicular tissue protein Li 199; thioredoxin; thioredoxin 1; thioredoxin delta 3; TRDX; TRX; TRX1; Txn; TXN delta 3; Txn1

more info or order :

Invitrogen product webpage