Phospho-SMAD3 (Ser423, Ser425) Monoclonal Antibody (S.434.0) | Invitrogen MA5-14936 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-SMAD3 (Ser423, Ser425) Monoclonal Antibody (S.434.0)

catalog :

MA5-14936

quantity :

100 uL

price :

US 470.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

S.434.0

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000; fig 3	Wang J, Liang W, Cui Y, He J, Liu H, Wang Y, et al. Noncanonical Activin A Signaling in PC12 Cells: A Self-Limiting Feedback Loop. Neurochem Res. 2016;41:1073-84 pubmed publisher
western blot; rat	Li J, Li P, Zhang Y, Li G, Zhou Y, Yang K, et al. c-Ski inhibits the proliferation of vascular smooth muscle cells via suppressing Smad3 signaling but stimulating p38 pathway. Cell Signal. 2013;25:159-67 pubmed publisher
	Wu S, Xia Y, Yang C, Li M. Protective effects of aloin on asthmatic mice by activating Nrf2/HO-1 pathway and inhibiting TGF-β/Smad2/3 pathway. Allergol Immunopathol (Madr). 2023;51:10-18 pubmed publisher
	ShamsEldeen A, Al Ani B, Ebrahim H, Rashed L, Badr A, Attia A, et al. Resveratrol suppresses cholestasis-induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. Clin Exp Pharmacol Physiol. 2021;48:1402-1411 pubmed publisher
	Xie X, Urabe G, Marcho L, Williams C, Guo L, Kent K. Smad3 Regulates Neuropilin 2 Transcription by Binding to its 5' Untranslated Region. J Am Heart Assoc. 2020;9:e015487 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-SMAD3 (Ser423, Ser425) Monoclonal Antibody (S.434.0)

Catalog # :

MA5-14936

Quantity :

100 uL

Price :

US 470.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ChIP Assay: 1:100, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Clone :

S.434.0

Isotype :

IgG

Storage :

-20 C

Description :

SMAD3 belongs to the SMAD family of proteins. They are similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Immunogen :

Synthetic phosphopeptide corresponding to residues surrounding pSer423/425 of Smad3

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1:100, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Aliases :

AU022421; DKFZp586N0721; DKFZp686J10186; hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; MAD homolog 3a; mad homolog JV15-2; mad protein homolog; MAD, mothers against decapentaplegic homolog 3; mad3; MAD-3; madh3; madh3a; madh3-A; MGC60396; mMad3; mothers against decapentaplegic homolog 3; mothers against decapentaplegic homolog 3a; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD; Smad 3; SMAD family member 3; SMAD family member 3 L homeolog; SMAD family member 3a; SMAD, mothers against DPP homolog 3; Smad3; smad3.L; smad3a; TGF beta response effector Smad3; TGF-beta response effector Smad3; transcription factor; transcription factor Smad3; wu:fa99e03; XELAEV_18018454mg; XenMLP; Xmad3; XSmad3

more info or order :

Invitrogen product webpage