TCF7L2 Monoclonal Antibody (T.473.8) | Invitrogen MA5-14935 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCF7L2 Monoclonal Antibody (T.473.8)

catalog :

MA5-14935

quantity :

100 uL

price :

US 474.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

T.473.8

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Zhang K, Qiu W, Li H, Li J, Wang P, Chen Z, et al. MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335-5p signaling pathway. J Orthop Translat. 2023;39:177-190 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TCF7L2 Monoclonal Antibody (T.473.8)

Catalog # :

MA5-14935

Quantity :

100 uL

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

ChIP Assay: 10 uL, Immunocytochemistry: 1:100, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Species :

Human

Clone :

T.473.8

Isotype :

IgG

Storage :

-20 C

Description :

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.

Immunogen :

Synthetic peptide corresponding to residues surrounding Leu331 of human TCF4

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 10 uL, Immunocytochemistry: 1:100, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Aliases :

HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; mTCF-4; mTcf-4B; mTcf-4E; RP11-357H24.1; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF 4; TCF4; TCF-4; TCF4B; TCF4E; Tcf7l2; TCF7L2 protein; transcription factor 7 like 2; transcription factor 7 like 2, T cell specific, HMG box; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; transcription factor Tcf4