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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
AKT Pan Monoclonal Antibody (J.314.4)
catalog :
MA5-14916
quantity :
100 uL
price :
US 524.00
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
J.314.4
reactivity :
human, mouse, rat, fruit fly
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 7
Published Application/Species/Sample/DilutionReference
  • western blot; rat; loading ...; fig 3d
Bazzari F, Abdallah D, El Abhar H. Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer's Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats. Molecules. 2019;24: pubmed publisher
Zhuo L, Hu Z, Chang J, Guo Q, Guo J. MicroRNA‑203a‑3p improves bleomycin and pingyangmycin sensitivity by inactivating the PI3K/AKT pathway in hemangioma. Exp Ther Med. 2024;27:80 pubmed publisher
Lisi L, Pizzoferrato M, Ciotti G, Martire M, Navarra P. mTOR Inhibition Is Effective against Growth, Survival and Migration, but Not against Microglia Activation in Preclinical Glioma Models. Int J Mol Sci. 2023;24: pubmed publisher
Li J, Jiang J, Chen Y, Lu W. KLF2 inhibits colorectal cancer progression and metastasis by inducing ferroptosis via the PI3K/AKT signaling pathway. J Pathol Clin Res. 2023;9:423-435 pubmed publisher
Wang H, Chinnathambi A, Alahmadi T, Alharbi S, Veeraraghavan V, Krishna Mohan S, et al. Phyllanthin inhibits MOLT-4 leukemic cancer cell growth and induces apoptosis through the inhibition of AKT and JNK signaling pathway. J Biochem Mol Toxicol. 2021;35:1-10 pubmed publisher
He A, Ma L, Huang Y, Zhang H, Duan W, Li Z, et al. CDKL3 promotes osteosarcoma progression by activating Akt/PKB. Life Sci Alliance. 2020;3: pubmed publisher
Wang Z, Li R, Zhong R. Extracellular matrix promotes proliferation, migration and adhesion of airway smooth muscle cells in a rat model of chronic obstructive pulmonary disease via upregulation of the PI3K/AKT signaling pathway. Mol Med Rep. 2018;18:3143-3152 pubmed publisher
product information
Product Type :
Antibody
Product Name :
AKT Pan Monoclonal Antibody (J.314.4)
Catalog # :
MA5-14916
Quantity :
100 uL
Price :
US 524.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Drosophila, Human, Mouse, Non-human primate, Rat
Applications :
Flow Cytometry: 1:100-1:400, Immunocytochemistry: 1:200-1:800, Immunohistochemistry (Paraffin): 1:150-1:600, Immunoprecipitation: 1:50, Western Blot: 1:1,000
Species :
Drosophila, Human, Mouse, Non-human primate, Rat
Clone :
J.314.4
Isotype :
IgG
Storage :
-20 C
Description :
AKT also known as protein kinase B (PKB) or RAS-alpha, is an ubiquitous serine/threonine kinase that plays an important role in diverse biological responses such as regulation of metabolism, cell survival and growth by phosphorylating multiple proteins. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.
Immunogen :
Synthetic peptide corresponding to residues in the carboxy-terminal sequence of mouse Akt
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:100-1:400, Immunocytochemistry: 1:200-1:800, Immunohistochemistry (Paraffin): 1:150-1:600, Immunoprecipitation: 1:50, Western Blot: 1:1,000
Aliases :
2410016A19Rik; AI851531; akt; Akt kinase; AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT serine/threonine kinase 3; Akt/PKB; Akt1; AKT1 kinase; AKT1m; Akt1m protein; Akt1-PA; Akt1-PB; Akt1-PC; Akt1-PD; Akt1-PE; Akt2; AKT2 kinase; AKT3; AKT3 kinase; akt3a; AW554154; bovine protein kinase B; cb945; CG4006; CG4006-PA; CG4006-PB; CG4006-PC; CG4006-PD; CG4006-PE; CWS6; D930002M15Rik; DAKT; D-Akt; dAkt kinase; dAKT/dPKB; dAkt/PKB; DAKT1; DAKT1/PKB; DKFZp434N0250; Dmel CG4006; Dmel_CG4006; DPKB; DRAC-PK; DRAC-PK66; DRAC-PK85; HIHGHH; kinase Akt1; l(3)04226; l(3)89Bq; MGC99656; MPPH; MPPH2; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 1; murine thymoma viral (v-akt) oncogene homolog 2; Nmf350; pAkt; P-AKT; pan akt; PKB; PKB alpha; PKB beta; PKB gamma; PKB/Akt; PKB/dAKT; PKBalpha; PKB-ALPHA; PKBB; PKBbeta; Pkbg; PKBgamma; PKB-GAMMA; PRKBA; PRKBB; PRKBG; Protein kinase Akt-2; protein kinase Akt-3; Protein kinase B; protein kinase B alpha; Protein kinase B beta; protein kinase B gamma; protein kinase B, beta; protein kinase B, gamma; protein kinase B-alpha; protein kinase; AKT1; proto-oncogene c-AKT; putative v-akt murine thymoma viral oncoprotein 2; RAC; rac protein kinase alpha; RAC protein kinase alpha RAC-PK alpha; rac protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC serine/threonine protein kinase; RAC serine/threonine-protein kinase; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-BETA; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RacPK; RAC-PK-alpha; RAC-PK-beta; RAC-PK-gamma; related to A and C kinases; related to PKA to PKC protein kinases; related to the A and C kinases; SD10374p; serine/threonine protein kinase; serine-threonine protein kinase; si:ch211-221n23.2; STK-2; Thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; thymoma viral proto-oncogene 2; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene homolog 2; v-akt murine thymoma viral oncogene homolog 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); v-akt murine thymoma viral oncogene homolog 3a; v-akt murine thymoma viral oncogene-like 1; v-akt murine thymoma viral oncogene-like 3; v-akt murine thymoma viral oncogene-like protein 1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA