CDK9 Monoclonal Antibody (K.513.1) | Invitrogen MA5-14912 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CDK9 Monoclonal Antibody (K.513.1)

catalog :

MA5-14912

quantity :

100 uL

price :

US 464.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

K.513.1

reactivity :

Chinese hamsters, human, mouse, rat, dogs, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 6b	Niu Q, Liu Z, Alamer E, Fan X, Chen H, Endsley J, et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019;129:3361-3373 pubmed publisher
	Somarelli J, Roghani R, Moghaddam A, Thomas B, Rupprecht G, Ware K, et al. A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer. Mol Cancer Ther. 2020;19:2516-2527 pubmed publisher
	Alamer E, Zhong C, Liu Z, Niu Q, Long F, Guo L, et al. Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective Small Molecule Modulator ZL0580. J Virol. 2020;94: pubmed publisher

product information

Product Type :

Antibody

Product Name :

CDK9 Monoclonal Antibody (K.513.1)

Catalog # :

MA5-14912

Quantity :

100 uL

Price :

US 464.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Rat

Applications :

Flow Cytometry: 1:100-1:400, Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:100-1:400, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Species :

Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Rat

Clone :

K.513.1

Isotype :

IgG

Storage :

-20 C

Description :

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.

Immunogen :

Synthetic peptide corresponding to residues near the carboxy terminus of human CDK9

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:100-1:400, Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:100-1:400, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Aliases :

C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit

more info or order :

Invitrogen product webpage