NUMB Monoclonal Antibody (S.925.4) | Invitrogen MA5-14897 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NUMB Monoclonal Antibody (S.925.4)

catalog :

MA5-14897

quantity :

100 uL

price :

US 524.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

S.925.4

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 1

Reference
Zuidema A, Wang W, Kreft M, Te Molder L, Hoekman L, Bleijerveld O, et al. Mechanisms of integrin αVβ5 clustering in flat clathrin lattices. J Cell Sci. 2018;131: pubmed publisher

product information

Product Type :

Antibody

Product Name :

NUMB Monoclonal Antibody (S.925.4)

Catalog # :

MA5-14897

Quantity :

100 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:200, Immunocytochemistry: 1:100, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Species :

Human

Clone :

S.925.4

Isotype :

IgG

Storage :

-20 C

Description :

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.

Immunogen :

Synthetic peptide corresponding to residues surrounding Phe482 of human Numb protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:200, Immunocytochemistry: 1:100, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Aliases :

c14_5527; C14orf41; h-Numb; mnb; m-Nb; m-numb; Nb; NUMB; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila); NUMB isoform 3; Numb variant 1; Numb variant 2; NUMB, endocytic adaptor protein; protein numb homolog; Protein S171; PTB domain protein; S171